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Table 1 Clinical and functional characteristics of the study patients

From: Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions

Anthropometric variables Lung cancer N = 20 Lung cancer-COPD N = 20
Age, years 64 (12) 65 (9)
Male, N/female, N 13/7 20/0
BMI, kg/m2 26 (5) 26 (5)
Smoking history
 Current: N, % 12, 60 14, 70
 Ex-smoker: N, % 5, 25 6, 30
 Never smoker: N,% 3, 15 0, 0
 Pack-years 53 (25) 57 (20)
Lung function testing
 vFEV1, % pred 92 (8) 61 (14)¶¶¶
 FEV1/FVC, % pred 77 (6) 60 (8)¶¶¶
 DLCO, % pred 88 (12) 72 (21)¶¶¶
 KCO, % pred 88 (11) 73 (17)¶¶¶
TNM staging
 Stage IA: N, % 5, 25 5, 25
 Stage IB: N, % 0, 0 4, 20
 Stage IIA: N, % 1, 5 6, 30
 Stage IIB: N, % 4, 20 2, 10
 Stage IIIA: N, % 3, 15 3, 15
 Stage IIIB: N, % 4, 20 0, 0
 Stage IV: N, % 3, 15 0, 0
Histological diagnosis
 Squamous cell carcinoma: N, % 6, 30 5, 25
 Adenocarcinoma: N, % 11, 55 14, 70
 Others: N, % 3, 15 1, 5
Blood parameters
 Total leucocytes/μL 8.3 103 (1.9 103) 9.2 103 (2.1 103)
 Total neutrophils/μL 5.7 103 (2.1 103) 6.3 103 (1.7 103)
 Total lymphocytes/μL 1.7 103 (650) 2.1·103 (617)
 Albumin (g/dL) 4.4 (0.4) 4.0 (0.5)¶¶
 Total proteins (g/dL) 7.4 (0.5) 7.1 (0.6)
 Fibrinogen (mg/dL) 485 (99) 409 (77)¶¶
 CRP (mg/dL) 1.1 (1.1) 1.7 (1.2)
 GSV (mm/h) 20 (7.4) 30 (16.8)
 Ceruloplasmin (g/dL) 26.2 (4.8) 26.5 (4.8)
Body weight loss, kg
 0, N, % 18, 90 17, 85
 1–4, N, % 2, 10 1, 5
 5–8, N, % 0, 0 2, 10
 9–12, N, % 0, 0 0, 0
  1. Continuous variables are presented as mean (standard deviation), while categorical variables are presented as the number of patients in each group and percentage of the total population
  2. Abbreviations: N number, kg kilograms, m meters, BMI body mass index, FEV 1 forced expiratory volume in the first second, pred predicted, FVC forced vital capacity, DLco, carbon monoxide transfer, K CO Krogh transfer factor, TNM tumor, nodes, metastasis, CRP C-reactive protein, GSV globular sedimentation velocity, L liter
  3. p < 0.05, ¶¶p < 0.01, ¶¶¶p < 0.001 between LC-COPD and LC patients. Comparisons of the clinical and physiological variables between LC-COPD and LC patients were assessed using the Student’s t test. Differences between the study groups in the qualitative variables were assessed using the chi-square test