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Table 2 The top-20 of differentially methylated positions representing changes in DNA methylation that differ between participants receiving folic acid and vitamin B12 or placebo

From: The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

       Mean change in methylation (%)
CpG Chr Gene Gene feature p value Adjusted p value Folic acid and vitamin B12 Placebo
cg19380919 2 9.9E-08 0.0426 1.0 −1.4
cg05308617 3 ARMC8 TSS200 8.4E-07 0.1810 0.6 −0.6
cg06016645 10 NODAL 3′UTR 1.6E-06 0.2323 1.5 −0.8
cg11567849 6 REV3L Body 2.7E-06 0.2495 0.8 −1.0
cg10367137 10 3.8E-06 0.2495 0.7 −1.1
cg18514573 6 4.0E-06 0.2495 0.6 −0.6
cg03330920 16 IFT140 Body 4.6E-06 0.2495 1.9 −2.1
cg01129246 4 GRXCR1 Body 4.9E-06 0.2495 2.6 −4.1
cg16895973 11 TOLLIP Body 6.0E-06 0.2495 1.3 −2.6
cg09708616 6 6.3E-06 0.2495 1.4 −1.3
cg04530976 6 ZBTB9 Body 6.4E-06 0.2495 0.8 −0.9
cg27610561 20 SLC2A10 TSS1500 8.2E-06 0.2665 1.0 −1.6
cg05119686 10 8.7E-06 0.2665 1.5 −1.1
cg03761210 20 NECAB3;C20orf144 Body 8.7E-06 0.2665 0.3 −0.3
cg07292606 2 TEX261 Body 9.4E-06 0.2665 2.0 −0.9
cg27194173 10 ADK Body 9.9E-06 0.2665 1.9 −0.9
cg06191076 1 DIRAS3 TSS200 1.3E-05 0.3192 2.7 −2.5
cg00066153 11 ACRV1 1stExon; 5′UTR 1.3E-05 0.3192 1.1 −0.9
cg20455570 7 OSBPL3 5′UTR 1.7E-05 0.3888 1.2 −1.0
cg24106824 17 MRPL12 3′UTR 2.0E-05 0.4105 1.1 −0.6
  1. Mean changes in methylation are presented as beta-values ranging from 0–100 %. The adjusted p values for the comparisons between the two groups control the false discovery rate using the Benjamini-Hochberg procedure. Abbreviations: Chr chromosome, TSS200 200 base pairs around the transcription start site, TSS1500 1500 base pairs around the transcription start site, 3′UTR 3′ untranslated region, 5′UTR 5′ untranslated region