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Table 1 Characteristics of the participants at baseline and after 2 years of intervention with either folic acid and vitamin B12 or placebo

From: The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

  Folic acid and vitamin B12 (n = 44) Placebo (n = 43)
Baseline characteristics   
 Age at baseline (years) 70.8 ± 2.9 71.1 ± 3.0
 Women (%) 25 (57 %) 22 (51 %)
 Body mass index (kg/m2) 27.2 (24.4–29.7) 28.7 (25.7–31.2)
 Smoking (%)a   
 Former 25 (57 %) 31 (72 %)
 Never 19 (43 %) 12 (28 %)
MTHFR C677T genotype (%)b   
 CC 22 (50 %) 20 (47 %)
 TT 22 (50 %) 23 (54 %)
Biochemical analyses   
Serum folate levels (nmol/L)   
 Baseline 16.2 (13.1–24.4) 17.3 (14.1–21.5)
 After intervention 52.3 (45.1–67.6) 23.1 (18.3–26.9)
 Change 34.0 (26.5–47.6) 5.4 (2.0–9.6)
Serum vitamin B12 levels (pmol/L)   
 Baseline 279 (232–358) 300 (204–365)
 After intervention 595 (467–814) 325 (230–449)
 Change 319 (197–462) 30.4 (−12.6–89.5)
Plasma homocysteine levels (μmol/L)   
 Baseline 14.7 (13.1–16.3) 14.9 (13.1–16.3)
 After intervention 9.6 (8.5–11.1) 13.7 (11.8–16.6)
 Change −5.3 (−6.7 to −3.4) −1.5 (−2.4–0.6)
  1. Data are presented as median (interquartile ranges) or numbers (%). aCurrent smokers were not selected for the study population. bSingle nucleotide polymorphism: rs1801133, participants with the CT genotype were not selected for the current study