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Table 2 DNA methylation scores before and after dexamethasone 4 mg/day for 4 days

From: Evidence for transcript-specific epigenetic regulation of glucocorticoid-stimulated skeletal muscle 11β-hydroxysteroid dehydrogenase-1 activity in type 2 diabetes

Methylation site Before dexamethasone (%) After dexamethasone (%) P value
P1 promoter CpG 32 (29 to 35) 30 (28 to 33) 0.026
P2 promoter (CpG mean) 42 (37 to 43) 38 (36 to 41) 0.093
  (P2_CpG 2) 22 (16 to 24) 18 (17 to 22) 0.072
  (P2 _CpG 3) 41 (33 to 44) 37 (35 to 42) 0.409
  (P2 _CpG 4) 63 (58 to 66) 59 (56 to 62) 0.065
  1. Data presented as median (25th to 75th percentile). Methylation scores (approximating % of alleles with cytosine methylation at specific CpG sites within a tissue sample) were obtained from the Mass Spec output using EpiTYPER v1.0.5 software (Sequenom Inc, San Diego, CA, USA). Only a single CpG site was present in the P1 promoter region tested, whereas three sites in close proximity were assessed in P2.