Fig. 3

Inducing small molecule non-coding RNAs to block CDK1-mediated EZH2 degradation of tumors in HNSCC. Transcription factors, which are DNA-binding proteins, play a crucial role in activating small non-coding RNAs and directly interacting with EZH2 within the nucleus of HNSCC. This specific interaction acts as an inhibitor, preventing the CDK1-mediated phosphorylation of EZH2 at the T345 and T487 sites. Furthermore, the presence of small non-coding RNAs effectively hinders the translocation of EZH2 from the nucleus to the cytoplasm, consequently resulting in ubiquitination and subsequent degradation of EZH2 by the proteasome [110]