Fig. 2

The epigenetic regulation of PRC2/EZH2 occurs in various tumors. In recent years, there have been reports of frequent overexpression of EZH2 in various human epithelial tumors, such as prostate cancer, breast cancer, gastric cancer, non-small cell lung cancer, esophageal cancer, melanoma, oral cancer, and endometrial cancer. Moreover, its overexpression has been correlated with enhanced tumor cell proliferation and unfavorable prognosis [65, 111]