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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma

Fig. 1

The mechanism of epigenetic regulation of PcG. The core of PRC1 primarily consists of really interesting new gene 1A and 1B (RING1A/RING1B), while the core of PRC2 mainly comprises embryonic ectoderm development (EED), retinoblastoma binding protein 4/7 (RBBP4/7), and EZH1/2. PRC2 deposits trimethylation of H3K27me3 to genomic loci. Then, related proteins drive cPRC1 to PRC2 pre-occupied loci and deposit monoubiquitylation of histone H2A at lysine 119 H2AK119ub1 [109]

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Clinical Epigenetics

ISSN: 1868-7083

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