Fig. 6

The significant inhibition of tumor growth in vivo by the histone demethylase inhibitor GSK-J4. A The experimental design for the in vivo experiments. B The effect of GSK-J4 on the body weight of nude mice. C), D, and E demonstrate the impact of GSK-J4 on tumor volume and tumor weight, respectively. F the results of HE staining of tumor tissues subjected to different treatments. The images at 10 × magnification have a scale bar of 200 μm (upper), while the images at 40 × magnification have a scale bar of 50 μm (lower), (n = 7). *p < 0.05; **p < 0.01; ***p < 0.001 compared with DMSO Ctrl