Fig. 2

The significant inhibitory effect of selenium on tumor growth in vivo. A The experimental scheme for the in vivo studies. B The effects of SeO₂ on the body weight of the inoculated nude mice Tumors from mice received different treatments. The tumor volume and weight were notably reduced by SeO₂ treatment, as demonstrated in panels C, D, and E. F HE staining of the tumor tissues in the SeO₂ group revealed tumor cells undergoing necrosis, apoptosis, nuclear fragmentation, and dissolution, (n = 7). The images were captured at 10 × magnification, with a scale bar of 200 μm, and at 40 × magnification, with a scale bar of 50 μm. *p < 0.05; **p < 0.01 compared with Ctrl (PBS treatment)