Fig. 8

Effects of shDNMT1, miR-152-3p mimic, and siSOS1 on self-renewal and tumor growth of A549-derived LCSLCs DNMT1 A DNMT1 activity; B DNMT1 mRNA and protein levels; C miR-152-3p levels; D SOS1 mRNA and protein levels; E Rates of sphere and colony formation (scale bar, 100 μm). All experiments were conducted in triplicate. *p < 0.05; ** p < 0.01; ***p < 0.001 vs. NC