Fig. 3

Depletion of miR-182 accelerates the development of murine BCR-ABL (P190)-transformed B-ALL. A and B The percentages of GFP⁺ cells were determined in PB (A, n = 3 for WT and KO mice) and BM cells (B, n = 3 for WT and KO mice) from 182WT and 182KO ALL mice. Shown are the representative plots (left) and statistical analysis of the percentages of GFP⁺ cells (right). (C and D) Wright-Giemsa staining for the PB (C) and BM (D) cells. Representative pictures (left) and statistical analysis of the percentages of blasts (right) are shown. The bar represents 20 μm. E and F Spleen (E) and liver (F) weights were measured in 182WT and 182KO ALL mice (n = 3 for WT and KO mice). Shown are the representative pictures (left) and statistical analysis of the spleen and liver weights (right). G and H HE staining of spleen (G) and liver (H) tissues from 182WT and 182KO ALL mice. The bar represents 50 μm.*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001