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Table 2 Percent methylation of the 4 CpGs of the 1st enhancer of CDH1 gene in ileal mucosa and PBMC

From: Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease

 

Crohn Disease

N = 21

Controls

N = 16

P value

Ileal mucosa:

 CpG-4414

34 ± 12

26 ± 12

0.02

 CpG-4512

58 ± 11

48 ± 11

0.01

 CpG-4584

33 ± 11

26 ± 11

0.03

 CpG-4628

56 ± 17

42 ± 17

0.01

 Average CpGs

45 ± 17

35 ± 17

 < 0.001

PBMC:

 CpG-4414

29 ± 5

31 ± 4

NS

 CpG-4512

46 ± 4

45 ± 5

NS

 CpG-4584

30 ± 4

32 ± 4

NS

 CpG-4628

43 ± 4

43 ± 4

NS

 Average CpGs

37 ± 9

38 ± 4

NS

  1. Mean (± SD); decimal values rounded to the nearest integer
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Clinical Epigenetics

ISSN: 1868-7083

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