Fig. 4

Promoter DNA methylation analysis of the PGRMC1, UNC119B, FNDC3B, and RERE genes in low-dose irradiated HAECs. A Schematic representation of the CpG island structures within the promoter regions of PGRMC1, UNC119B, FNDC3B, and RERE. Amplicon for MSP analysis is indicated with a green bar. B Quantitative MSP of the four genes in irradiated HAECs and controls. All quantitative methylation levels were normalized by the Alu element. Statistical analysis data are presented as mean ± SD, black dots indicate replicates (n = 4). *p < 0.05; **p < 0.01; ***p < 0.01 compared with control