Fig. 2

Genome-wide differentially methylated regions in irradiated HAECs and HCAECs. A, B Genome-wide DNA methylation levels were compared between irradiated HAECs and HCAECs and control using the HumanMethylationEPIC BeadChip platform. A total of 1064 (HAECs) and 483 (HCAECs) CpG sites were hypermethylated, whereas 392 (HAECs) and 573 (HCAECs) CpG sites were hypomethylated. P values were calculated using the Mann–Whitney U test. The pie chart illustrates the distribution of genome-wide coverage among differentially methylated regions. The promoter, intergenic region, gene body, exons, and other regions are shown