Fig. 5

Effect of VX-765 on the induction of pyroptosis. A Representative western blot pictures showing Caspase-1 and GSDMD expressions. B, C Densitometric quantification of Caspase-1 (*P = 0.012, ^#P = 0.037) and GSDMD (*P = 0.024, ^#P = 0.013) expressions. D LDH measured by ELSIA (*P = 0.047, ^#P = 0.026). (E) Cell viability measured by MTT (*P = 0.018, ^#P = 0.006). *P < 0.05, versus control, ^#P < 0.05, versus siSirt6