From: Evaluation of pediatric epigenetic clocks across multiple tissues
Tissue | Array | Birth term | GA (weeks) | N | NeoAge PMAỻ | Knight | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Post-menstrual age (weeks) estimation | ||||||||||||
Blood spot | 450K | Term | 39.36 ± 1.91 | 253 | 0.18 | 4.72 | 0.29 | − 4.71 | 0.35 | 1.11 | 0.96 | − 0.08 |
EPIC | Term | 38.73 ± 1.60 | 176 | 0.27 | 3.08 | 0.21 | − 2.85 | 0.48 | 0.89 | 0.91 | − 0.32 | |
EPIC | Preterm | 25.65 ± 1.27 | 272 | 0.27 | 8.31 | 0.29 | 8.53 | 0.57 | 2.52 | 1.01 | 2.52 |
Tissue | Array | Birth term | GA (weeks) | N | NeoAge PMAỻ | Lee | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Placenta | EPIC | Term | 38.79 ± 1.18 | 121 | 0.16 | 1.91 | 0.39 | − 2.01 | 0.36 | 0.88 | 0.76 | − 0.32 |
Preterm | 25.68 ± 1.25 | 399 | 0.15 | 9.88 | 0.36 | 10.13 | 0.6 | 2.50 | 0.93 | 2.59 |
Tissue | Array | Birth term | GA (weeks) | N | NeoAge PMAỻ | Knight | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Buccal cells | EPIC | Term | 38.13 ± 1.09 | 72 | 0.44 | 0.98 | 0.44 | − 0.87 | 0.25 | 11.01 | 0.59 | − 10.96 |
Buccal cells¶ | EPIC | Preterm | 26.63 ± 1.89 | 480 | 0.99 | 0.71 | 0.23 | − 0.78 | − 0.06 | 2.00 | 0.74 | − 0.75 |
Tissue | Array | Birth term | Age (weeks) | N | NeoAge PNA (weeks) | PedBE (weeks) | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Post-natal age (weeks) estimation | ||||||||||||
Buccal cells | EPIC | Term | 0.52 ± 0.75 | 72 | − 0.02 | 7.35 | 0.65 | 7.44 | 0.12 | 2.66 | 2.53 | 2.30 |
Buccal cells¶ | EPIC | Preterm | 12.14 ± 4.52 | 480 | 1 | 1.00 | 0.20 | − 1.19 | 0.62 | 4.46 | 4.70 | 3.38 |