From: Evaluation of pediatric epigenetic clocks across multiple tissues
Tissue | Array | Birth term | GA (weeks) | N | Knight | Bohlin | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Gestational age (weeks) estimation | ||||||||||||
Blood spot | 450K | Term | 39.36 ± 1.91 | 253 | 0.35 | 1.11 | 0.96 | − 0.08 | 0.47 | 1.02 | 0.52 | − 0.94 |
EPIC | Term | 38.73 ± 1.60 | 176 | 0.48 | 0.89 | 0.91 | − 0.32 | 0.65 | 1.42 | 0.43 | − 1.35 | |
EPIC | Preterm | 25.65 ± 1.27 | 272 | 0.57 | 2.52 | 1.01 | 2.52 | 0.67 | 3.91 | 0.51 | 4.01 | |
CBMC | EPIC | Term | 38.98 ± 1.39 | 142 | 0.38 | 2.02 | 0.83 | − 1.90 | 0.66 | 1.73 | 0.35 | − 1.56 |
Cord blood | 27K | Term | 39.00 ± 1.29 | 159 | 0.31 | 1.10 | 0.97 | − 0.39 | 0.37 | 0.58 | 0.14 | − 0.31 |
450K | Term | 39.19 ± 1.43 | 1194 | 0.41 | 0.98 | 0.82 | − 0.45 | 0.57 | 1.10 | 0.46 | − 0.99 | |
EPIC | Term | 38.92 ± 1.74 | 585 | 0.34 | 1.11 | 0.91 | − 0.49 | 0.55 | 1.64 | 0.52 | − 1.41 |
Tissue | Array | Birth term | GA (weeks) | N | Lee | Mayne | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Placental gestational age (weeks) estimation | ||||||||||||
Placenta | 450K | Term | 38.98 ± 1.15 | 59 | 0.5 | 0.60 | 0.52 | − 0.11 | 0.27 | 1.55 | 0.83 | − 1.62 |
EPIC | Term | 38.79 ± 1.18 | 121 | 0.36 | 0.88 | 0.76 | − 0.32 | − 0.05 | 2.11 | 1.37 | 0.92 | |
Preterm | 25.68 ± 1.25 | 399 | 0.6 | 2.50 | 0.93 | 2.59 | 0.35 | 7.27 | 1.22 | 7.38 |
Tissue | Array | Birth term | Age (days) | N | Horvath | PedBE | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
\(r\)* | Median error† | Median res§ | Mean diff‡ | \(r\)* | Median error† | Median res§ | Mean diff‡ | |||||
Pediatric chronological age (years) estimation | ||||||||||||
Buccal cells | EPIC | Term | 3.62 ± 5.24 | 72 | − 0.36 | 0.98 | 0.17 | 1.00 | 0.12 | 0.05 | 0.05 | 0.04 |
Preterm | 84.95 ± 31.64 | 480 | 0.41 | 1.15 | 0.34 | 1.26 | 0.62 | 0.09 | 0.09 | 0.07 | ||
PBMC | 450K | Term | 4044.20 ± 1098.28 | 150 | 0.79 | 1.72 | 1.26 | − 1.33 | 0.78 | 6.73 | 0.26 | − 5.29 |
EPIC | Term | 2555 | 140 | NA | 3.48 | 1.24 | 3.48 | NA | 0.83 | 0.38 | − 0.72 | |
Peripheral whole blood | 450K | Term | 2504.60 ± 705.79 | 307 | 0.68 | 0.85 | 0.86 | 0.30 | 0.56 | 1.73 | 0.30 | − 1.07 |
EPIC | Term | 153 ± 93.44 | 46 | 0.74 | 1.50 | 0.29 | 1.49 | 0.68 | 4.09 | 0.18 | 4.09 |