Fig. 3

Differential methylation in adenoma, carcinoma, and normal colorectal tissues in both EPIC and 450K datasets. A Barplot of DMP counts per genomic region for each of the 3 pairwise comparisons for both methylation platforms. Percentages are fractions of the total DMPs for each comparison and platform. B Barplot of hyper- (β ≥ 0.7) and hypomethylated (β ≤ 0.3) DMPs for each of the 3 comparisons for both methylation platforms. Percentages are fractions of the total DMPs for each comparison and platform. C Barplot of DMB and DMR counts for all 3 comparisons for both methylation platforms. Annotations in regular font are with reference to genes, those in bold are with reference to CpG islands. UTR untranslated region, IGR intergenic region, TSS transcription start site, N north, i.e., upstream (5’) of CpG island, S south, i.e., downstream (3’) of CpG island, ExonBnd exon boundaries, DMB differentially methylated block, DMR differentially methylated region