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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation

Fig. 6

ARID5B overexpression promotes the M0-to-M2 polarization of macrophages and apoptosis in monocytes/macrophages. THP-1-derived macrophages were induced using 50 ng/mL PMA. A The relative mRNA expression of CD86, TNF-α, Arg-1, IL-10, MCP-1, and ARID5B in M0 macrophages. B The effect of ARID5B on monocyte apoptosis (%). C The effect of ARID5B on macrophage apoptosis (%). All plotted values are the mean ± SE values of at least three independent experiments. WTM, wild-type monocyte-derived macrophage; OEM, ARID5B-overexpressing monocyte-derived macrophage; KOM, ARID5B-knockout monocyte-derived macrophage. *p < 0.05, **p < 0.01, ***p < 0.001

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Clinical Epigenetics

ISSN: 1868-7083

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