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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation

Fig. 1

Global 5-mC levels are negatively associated with the proportions of intermediate monocytes in CAD patients. A The proportions of monocyte subsets in CAD patients (n = 180) and healthy controls (n = 210) (%). B The expression levels (MFI) of CCR2 on monocyte subsets. C Global 5-mC levels in PBLs in CAD patients (n = 180) and healthy controls (n = 210) (%). D The relative mRNA expression of DNMT1 in CAD patients (n = 110) and healthy controls (n = 112). E Spearman correlation between global 5-mC levels and the proportions of intermediate monocytes in CAD patients (n = 180). F Global 5-mC levels in the monocyte subsets in the CAD (n = 15) and control (n = 8) groups (%). m1, classical monocytes; m2, intermediate monocytes; m3, nonclassical monocytes; MFI, median fluorescence intensity; Con, control; CAD, coronary artery disease; 5-mC, 5-methylcytosine. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001

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Clinical Epigenetics

ISSN: 1868-7083

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