| N | Associations between methylation score and BMI/birth weight | Associations between genetic score and BMI/birth weight | ||||
---|---|---|---|---|---|---|---|
Effect size1, in kg/m2 per SD in methylation score (CI) | p value | Adjusted R-squared3 | Effect size2 (CI) | p value | Adjusted R-squared3 | ||
Birth4 | 823 | 69.27 (35.35, 103.18) | 6.83E−05 | 0.02 | − 219.75 (− 412.59, − 26.90) | 0.03 | 0.004 |
Childhood | 906 | 0.25 (0.12, 0.39) | 2.23E−04 | 0.01 | 2.24 (1.45, 3.02) | 2.72E−08 | 0.03 |
Adolescence | 770 | 0.97 (0.69, 1.26) | 3.91E−11 | 0.03 | 5.25 (3.65, 6.85) | 2.12E−10 | 0.05 |
Pregnancy | 792 | 0.62 (0.36, 0.87) | 2.31E−06 | 0.02 | 2.91 (1.38, 4.43) | 1.95E−04 | 0.02 |
Middle-age | 726 | 2.06 (1.67, 2.46) | 1.58E−23 | 0.10 | 4.72 (2.54, 6.90) | 2.45E−05 | 0.02 |