Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein

Clinical Epigenetics

Table 2 The methylation status of CpG locus (the total and each tested) at AVPR1a gene promoter. The data was expressed as mean ± SEM. PE pre-eclampsia, NP normal pregnant. P < 0.01; *P < 0.001

Gene	Position	NP	PE
AVPR1a	1	0.104 ± 0.028	0.123 ± 0.028
	2	0.107 ± 0.032	0.119 ± 0.021
	3	0.165 ± 0.027	0.163 ± 0.010
	4	0.115 ± 0.015	0.122 ± 0.009
	5	0.094 ± 0.015	0.291 ± 0.064**
	6	0.112 ± 0.019	0.280 ± 0.066***
	7	0.092 ± 0.039	0.083 ± 0.014
	8	0.131 ± 0.028	0.111 ± 0.031
	9	0.047 ± 0.019	0.088 ± 0.026
	10	0.072 ± 0.018	0.088 ± 0.028
	11	0.043 ± 0.011	0.049 ± 0.016
	12	0.096 ± 0.019	0.131 ± 0.015
	13	0.102 ± 0.040	0.100 ± 0.034
	14	0.094 ± 0.021	0.100 ± 0.004
	Average	0.098 ± 0.013	0.132 ± 0.017*

ISSN: 1868-7083