| Cohort 1 (Illumina 450K) | Cohort 2 (Illumina Epic) | ||||
---|---|---|---|---|---|---|
Smokers (N = 361) | Non-smokers (N = 247) | p | Smokers (N = 309) | Non-smokers (N = 220) | p | |
HIV-positive (%) | 100 | 100 | N/A | 100 | 100 | N/A |
Age | 49.2 ± 6.74 | 49.7 ± 8.70 | 0.44 | 48.0 ± 6.55 | 48.3 ± 9.20 | 0.62 |
Sex (male, %) | 100 | 100 | N/A | 100 | 100 | N/A |
Race (AA, %) | 87.5 | 83.4 | 0.01 | 79 | 82.7 | 0.32 |
AUDIT-C | 4.00 ± 3.32 | 3.72 ± − 3.48 | 0.31 | 3.67 ± 3.05 | 2.99 ± 2.89 | 0.01 |
ART (%) | 76.5 | 76.1 | 0.87 | 69.6 | 83.2 | 0.0004 |
WBC | 5.35 ± 2.09 | 5.34 ± 1.81 | 0.95 | 5.27 ± 1.96 | 5.27 ± 1.55 | 0.99 |
CD4 | 408 ± 290 | 457 ± 272 | 0.04 | 415 ± 200 | 493 ± 280 | 0.002 |
VL (log10) | 2.75 ± 1.24 | 2.52 ± 1.15 | 0.03 | 2.82 ± 1.26 | 2.55 ± 1.20 | 0.02 |
CD8* | 0.18 ± 0.08 | 0.17 ± 0.08 | 0.40 | 0.16 ± 0.08 | 0.17 ± 0.08 | 0.38 |
CD4* | 0.05 ± 0.05 | 0.05 ± 0.05 | 0.33 | 0.07 ± 0.05 | 0.08 ± 0.06 | 0.19 |
Nature killer cells* | 0.06 ± 0.05 | 0.09 ± 0.07 | < 0.0005 | 0.08 ± 0.05 | 0.09 ± 0.06 | < 0.005 |
B cell* | 0.09 ± 0.05 | 0.08 ± 0.05 | 0.47 | 0.11 ± 0.05 | 0.11 ± 0.04 | 0.44 |
Monocytes* | 0.12 ± 0.04 | 0.12 ± 0.04 | 0.83 | 0.11 ± 0.04 | 0.10 ± 0.04 | 0.002 |
Granulocytes* | 0.53 ± 0.13 | 0.51 ± 0.12 | 0.07 | 0.51 ± 0.11 | 0.49 ± 0.11 | 0.02 |