Table 1 Patient demographics and clinical characteristics
From: Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways
|  | Normal (N = 15) | Fibrosis (N = 15) | P value |
|---|---|---|---|
Female, n (%) | 15 (1.00) | 15 (1.00) | NS |
Mean age in years at biopsy (SD) | 47.1 (6.3) | 51.3 (8.2) | NS |
BMI at biopsy (SD) | 41.0 (4.6) | 44.4 (6.6) | NS |
Diabetes mellitus, n (%) | 6 (0.40) | 6 (0.40) | NS |
Laboratory measures, mean (SD) | |||
 Serum AST, U/L | 23.2 (4.2) | 47.5 (23.3) | .0004 |
 Serum ALT, U/L | 23.7 (8.1) | 47.3 (26.5) | .0027 |
 AST/ALT, U/L | 1.0 (0.3) | 1.0 (0.3) | NS |
 Alkaline phosphatase | 71.2 (15.9) | 91.6 (80.5) | NS |
 Total bilirubin | 0.49 (0.24) | 0.47 (0.18) | NS |
 Glucose (mg/dL) | 100.9 (31.9) | 120.2 (53.5) | NS |
 Insulin | 18.0 (13.2) | 39.7 (29.8) | .0155 |
 HbA1c, % (SD) | 6.0 (1.0) | 6.6 (1.3) | NS |
 Triglycerides | 142.9 (64.5) | 186.9 (67.2) | 0.04 |
 Total cholesterol | 179.7 (26.1) | 197.9 (33.9) | NS |
 LDL-C | 107.3 (14.4) | 116.5 (17.2) | NS |
 HDL-C | 55.9 (28.3) | 46.7 (32.4) | NS |
Histologic characteristics | |||
 Steatosis, mean grade (SD) | 0 | 2.1 (0.7) | < 0.0001 |
 Lobular inflammation, % = grade 1 | 0 | 0.47 | < 0.0001 |
 Lobular inflammation, % > grade 2 | 0 | 0.4 | < 0.0001 |
 Portal inflammation, (%) | 0 | 0.4 | < 0.0001 |
 Ballooning (mean score) | 0 | 1.3 (0.7) | < 0.0001 |