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Table 4 Associations of global 5-mC contents with CAD prevalence

From: Genomic 5-mC contents in peripheral blood leukocytes were independent protective factors for coronary artery disease with a specific profile in different leukocyte subtypes

 

Bottom tertilea

Middle tertile

Per SD decrease

Not adjusted

3.974 (2.552, 6.189)

3.393 (2.183, 5.237)

2.517 (1.951, 3.245)

Adjusted for age and sex

4.044 (2.589, 6.316)

3.433 (2.203, 5.349)

2.546 (1.971, 3.289)

Plus histories of HT, HL, and DM

4.048 (2.509, 6.532)

3.446 (2.153, 5.516)

2.577 (1.956, 3.395)

Plus PBL counts

5.165 (3.049, 8.750)

4.012 (2.391, 6.731)

2.816 (2.077, 3.816)

Plus PBL classifications

5.667 (3.312, 9.699)

4.195 (2.482, 7.093)

3.076 (2.245, 4.213)

  1. Data are odds ratio (95% CI). Odds ratio more than 1 indicates that the independent factor (i.e., global 5-mC contents divided in each group) is a risk factor. The top tertile was used as the reference group. Tertile cut-points were 3.77 and 4.43%, respectively, based on global 5-mC distributions among the whole samples (i.e., 535 participants)
  2. aFor trend, P < 0.001
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Clinical Epigenetics

ISSN: 1868-7083

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