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Table 3 Summary of CIs generated from the isobologram of increasing concentrations of chidamide and IDA, DNR, or Ara-C for CD34+CD38− KG1α cells

From: Cooperative effect of chidamide and chemotherapeutic drugs induce apoptosis by DNA damage accumulation and repair defects in acute myeloid leukemia stem and progenitor cells

Drugs (nM)

FA

Chidamide (μM)

FAChidamide

FAComb

CI

IDA

FAIDA

    

 20

0.087

0.5

0.044

0.179

0.610

 20

0.087

0.75

0.049

0.242

0.481

 40

0.229

0.5

0.044

0.468

0.516

 40

0.229

0.75

0.049

0.693

0.291

DNR

FADNR

    

 100

0.053

0.5

0.041

0.142

0.149

 100

0.053

0.75

0.042

0.166

0.107

 200

0.077

0.5

0.041

0.274

0.069

 200

0.077

0.75

0.042

0.422

0.022

Ara-C

FAAra-C

    

 500

0.128

0.5

0.041

0.200

0.220

 500

0.128

0.75

0.042

0.212

0.177

 1000

0.157

0.5

0.041

0.235

0.244

 1000

0.157

0.75

0.042

0.304

0.089

  1. CI less than 1.0 indicates synergistic effect. FAChidamide indicates fraction of cytotoxicity by chidamide alone; FAIDA, FADNR, and FAAra-C, fraction of cytotoxicity by IDA, DNR, or Ara-C alone, respectively; FAComb fraction of cytotoxicity by chidamide plus IDA, DNR, or Ara-C
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Clinical Epigenetics

ISSN: 1868-7083

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