Fig. 2From: Regulating role of fetal thyroid hormones on placental mitochondrial DNA methylation: epidemiological evidence from the ENVIRONAGE birth cohort studyEstimated proportion of effects of FT3 exposure on mtDNA content mediated by mtDNA methylation. The figure displays placental mtDNA methylation as mediator (left panel: MT-RNR1; right panel: D-loop), the estimates of indirect effect (IE), the estimates of the direct effect (DE), and proportion of mediation (IE/DE + IE). The effects represent a relative change (%) in placental mtDNA content for an increment between the 10th-90th percentile of FT3. All models were adjusted for maternal age, pre-pregnancy BMI, gestational age, newborn’s sex, smoking status, parity, maternal education, ethnicity, and cord plasma insulin level. * p-value < 0.05Back to article page