Cell-free DNA promoter hypermethylation in plasma as a diagnostic marker for pancreatic adenocarcinoma

Clinical Epigenetics

Table 3 Mean number of hypermethylated genes in each group

Group	N	Mean number of methylated genes	95% CI	p value
Pancreatic cancer	95	8.41	(7.62–9.20)
Control group 1; screened negative	27	4.89	(4.07–5.71)
Control group 2; chronic pancreatitis	97	4.34	(3.85–4.83)
Control group 3; acute pancreatitis	59	5.34	(4.77–5.91)
Control groups 1 + 2	124	4.46	(4.04–4.88)	<0.0001^a
Control groups 1 + 2 + 3	183	4.74	(4.40–5.08)	<0.0001^b

The means were compared as numerical data with nonparametric Wilcoxon rank sum test. p values less than 0.05 were considered statistically significant
^aSignificant difference between patients with pancreatic cancer and control groups 1 + 2
^bSignificant difference between patients with pancreatic cancer and control groups 1 + 2 + 3
CI confidential interval

ISSN: 1868-7083