Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model

Table 2 Overrepresentation analysis

Cohort	Comparison	Significance level	Expected probability	Probability estimate	Binomial test P value
GenRED Offspring Saliva, cortisol	Neuron, suicide	0.05	0.507	0.614	3.47 × 10⁻¹⁰²
		0.01	0.158	0.242	8.70 × 10⁻²⁸
		0.001	0.019	0.026	0.332
GenRED Offspring Blood, cortisol	Neuron, suicide	0.05	0.470	0.569	2.97 × 10⁻⁸⁶
		0.01	0.132	0.209	1.30 × 10⁻²⁶
		0.001	0.015	0.039	9.71 × 10⁻³
Combined GenRED Offspring Blood and saliva, cortisol	Neuron, suicide	0.05	0.522	0.618	1.68 × 10⁻⁸¹
		0.01	0.187	0.251	1.34 × 10⁻¹⁵
		0.001	0.032	0.035	0.851
Houtepen et al. [20] Cortisol	Neuron, suicide	0.05	0.470	0.578	2.01 × 10⁻¹⁰⁵
		0.01	0.119	0.193	6.02 × 10⁻³²
		0.001	0.011	0.029	3.15 × 10⁻³
Combined GenRED Offspring Blood and saliva, cortisol	Houtepen et al. [20] Cortisol	0.05	0.522	0.603	6.70 × 10⁻⁶⁰
		0.01	0.187	0.264	1.08 × 10⁻²⁵
		0.001	0.032	0.061	4.96 × 10⁻³

Overrepresentation analysis of genes significantly associated with AUC weekday cortisol measures in GenRED Offspring blood and saliva samples, genes significantly associated with suicide in postmortem prefrontal cortex neurons, and genes associated with AUC cortisol in blood from Houtepen et al. [20]

ISSN: 1868-7083