Table 1 Population and test characteristics by histologic category
From: Combined clinical and genetic testing algorithm for cervical cancer diagnosis
Histological results | Total | |||||||
|---|---|---|---|---|---|---|---|---|
Cutoff | Normal | CIN1 | CIN2 | CIN3 | CIS | SCC/AC | ||
Number of subjects | ||||||||
N (%) | 218 (48.55) | 30 (6.68) | 43 (9.58) | 72 (16.04) | 15 (3.34) | 71 (15.81) | 449 (100) | |
Age (years) | ||||||||
Mean ± SD (range) | 41.2 ± 10.6 (21.5 to 77.8) | 47.0 ± 9.6 (29.0 to 66.2) | 39.2 ± 11.1 (21.8 to 64.6) | 37.3 ± 5.1 (23.7 to 63.0) | 45.1 ± 8.7 (28.3 to 65.7) | 42.9 ± 4.5 (32.5 to 74.3) | 42.8 ± 10.3 (21.5 to 77.8) | |
Cytology results | ||||||||
Normal (%) | 90 (90.91) | 4 (4.04) | 2 (2.02) | 0 (0.00) | 1 (1.01) | 2 (2.02) | 99 (100) | |
ASC-US (%) | 112 (53.85) | 21 (10.10) | 32 (15.38) | 24 (11.54) | 5 (2.40) | 14 (6.73) | 208 (100) | |
LSIL (%) | 1 (16.67) | 2 (33.33) | 0 (0.00) | 3 (50.00) | 0 (0.00) | 0 (0.00) | 6 (100) | |
ASC-H/AGC/HSIL+ (%) | 15 (11.03) | 3 (2.21) | 9 (6.62) | 45 (33.09) | 9 (6.62) | 55 (40.44) | 136 (100) | |
Detection modality or test used | ||||||||
hrHPV (%) | 100 (45.87) | 18 (60.00) | 39 (90.70) | 71 (98.61) | 15 (100) | 69 (97.18) | 312 (69.49) | |
HPV16/18 (%) | 19 (8.72) | 5 (16.67) | 12 (27.91) | 36 (50.00) | 11 (73.33) | 56 (78.87) | 139 (30.96) | |
PAX1 m (%) | ΔCp ≦ 9.0 | 34 (15.60) | 4 (13.33) | 15 (34.88) | 47 (65.28) | 11 (73.33) | 52 (73.24) | 163 (36.30) |
ZNF582 m (%) | ΔCp ≦ 11.0 | 22 (10.09) | 6 (20.00) | 10 (23.26) | 48 (66.67) | 12 (80.00) | 61 (85.92) | 159 (35.41) |