From: Sirtuin functions and modulation: from chemistry to the clinic
Sirtuin | Localization | Enzymatic activity | Histone deacetylation target | Non-histone deacetylation target | Pathology |
---|---|---|---|---|---|
SIRT1 | Nuclear/cytoplasmatic | Deacetylase | H3K9ac | Hif-1α, Hif-2α | Neurodegenerative diseases. Cancer: acute myeloid leukemia, colon, prostate, ovarian, glioma, breast, melanoma, lung adenocarcinoma. |
H1K26ac | MYC | ||||
H4K16ac | |||||
SIRT2 | Nuclear/cytoplasmatic | Deacetylase | H3K56ac | Tubulin | Neurodegenerative diseases. Cancer: brain tissue, glioma. |
H4K16ac | Foxo3a | ||||
EIF5A | |||||
P53, G6PD, MYC | |||||
SIRT3 | Mitochondrial | Deacetylase | H3K56ac | SOD2, PDMC1a, IDH2, GOT2, FoxO3a | Neurodegenerative diseases. Cancer: B cell chronic lymphocytic leukemia, mantle cell lymphoma, chronic lymphocytic leukemia, breast, gastric. |
H4K14 ac | |||||
SIRT4 | Mitochondrial | ADP-ribosyltransferase | Unknown | GDH, PDH | Cancer: breast, colorectal. |
SIRT5 | Mitochondrial | Malonyl, succinyl, glutaryl deacetylase | Unknown | CPS1 | Cancer: pancreatic, breast, non-small cell lung carcinoma. |
SIRT6 | Nuclear | Deacetylase, ADP-ribosyltransferase, long-chain fatty acyl deacylase | H3K9ac | Unknown | Cancer: breast, colon. |
H3K56ac | |||||
SIRT7 | Nuclear | Deacetylase | H3K18ac | Hif-1α, Hif-2α | Cancer: liver, testis, spleen, thyroid, breast. |