DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Table 5 Significant mediating effects of gene methylation on IL-13 outcome

Gene	CpG site	DNA methylation				IL-13 outcome							Mediation effect
		R ²	Storm32			R ²	DNA methylation			Storm32			Mediation effect
		R ²	Effect (a)	SE	p val.	R ²	Effect (b)	SE	p val.	Effect (c')	SE	p val.	Effect (ab*)	Boot SE	Boot LLCI	Boot ULCI	Standardized Effect
LCK	cg17078393	0.2561	0.0659	0.0202	0.0027	0.1906	0.1831	0.1123	0.1133	0.0144	0.0146	0.3331	0.0121	0.0087	0.0003	0.0348	0.157233
LCK	cg05350315	0.1949	0.0711	0.026	0.0101	0.1727	0.1235	0.0883	0.1721	0.0177	0.0142	0.223	0.0088	0.0068	0.0001	0.028	0.144773

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