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Fig. 2 | Clinical Epigenetics

Fig. 2

From: DNA methylation mediates the effect of exposure to prenatal maternal stress on cytokine production in children at age 13½ years: Project Ice Storm

Fig. 2

Mediation analysis on the relationship between exposure to objective PNMS and cytokine production. Path “a” is the effect of the objective PNMS (predictor variable) on the DNA methylation (mediator), path “b” is the effect of the DNA methylation on cytokine production (outcome variable) controlling for the objective PNMS, and path “c’ ” is the direct effect of the objective PNMS on cytokine production controlling for the DNA methylation. The path “a*b” indicates the mediating effect of objective PNMS on cytokine production through DNA methylation (mediator). Path “c” is the total effect of objective PNMS on cytokine production.

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Clinical Epigenetics

ISSN: 1868-7083

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