From: Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
Chemical structure | Name | Target | Study phase |
---|---|---|---|
Hydroxamates | SAHA (vorinostat) | Pan-inhibitor | Phase III alone or in combination |
PXD101 (belinostat) | Pan-inhibitor | Phase II alone or in combination | |
LBH589 (panobinostat) | Pan-inhibitor | Phase II alone or in combination | |
ITF2357 (givinostat) | Pan-inhibitor | Phase II alone or in combination | |
4SC-201 (resminostat) | Pan-inhibitor | Phase II alone or in combination | |
PCI 24781 (abexinostat) | Classes I and II | Phase II alone or in combination | |
Cyclic peptides | Depsipeptide/FK228 (romidepsin) | Classes I | phase III alone or in combination |
Aliphatic fatty acids | Valproic acid | Classes I and IIa | Phase II alone or in combination |
Butyrate | Classes I and IIa | Phase II alone or in combination | |
Benzamides | MS-275 (entinostat) | Class I | Phase II alone or in combination |
MGCD0103 (mocetinostat) | Class I/IV | Phase II alone or in combination |