Fig. 4

Association between alteration patterns in netrin-1 receptors and clinicopathological features in gastric cancers. Correlation between alterations in netrin-1 receptors and TNM stage (a), depth of invasion (b), and degree of regional lymph node metastasis (c); association between alteration patterns in netrin-1 receptors and LOH ratio (d), presence of distant metastasis (e), MSI status (f), CIN phenotype (g), and KRAS/BRAF/PIC3CA mutation status (h). *The P value in panel A was calculated between Stage I/II vs. III/IV by Pearson’s chi-square test. ** The P value in panel c was calculated between N0 vs. N1–N3 by Pearson’s chi-square test. In Panel (d), the horizontal line within each box represents the median, the limits of each box represent the interquartile ranges, and the whiskers are the maximum and minimum values in the box plot diagrams. Asterisks and the numbers denote the mean value of the LOH ratio. Pairwise comparisons for each of the subgroups in panel (d) were performed by a non-parametric multiple comparison method using the Steel–Dwass test. ***Two cases could not be evaluated for CIN phenotype