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Figure 5 | Clinical Epigenetics

Figure 5

From: Genome-wide DNA methylation analysis reveals estrogen-mediated epigenetic repression of metallothionein-1 gene cluster in breast cancer

Figure 5

Basal level expression and DNA methylation for most of the genes in MT1 gene cluster show lower expression and higher methylation in breast cancer cell lines. (A) RT-qPCR gene expression and (B) averaged methylation profiles of MT1 genes in cell lines representing ERα + (MCF7 and BT474) and ERα − (BT20 and MDAMB231) subsets compared to normal (HMEC used for PCR and average of normal samples for DNA methylation) revealing lower levels of expression and higher levels of DNA methylation in cell lines compared to normal.

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Clinical Epigenetics

ISSN: 1868-7083

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