LINE-1 hypomethylation is neither present in rectal aberrant crypt foci nor associated with field defect in sporadic colorectal neoplasia

Table 3 LINE-1 methylation levels in normal mucosa stratifying by location of the neoplastic lesion

LINE-1 methylation	Patients with proximal adenoma (n = 10)^a	Patients with distal adenoma (n = 30)^a	P value	Patients with proximal^acolon cancer (n = 11)	Patients with distal colon cancer (n = 24)^a	P value
Normal rectal mucosa	73.87% (72.47 to 75.90)	76.06% (74.78 to 77.33)	0.087	77.59% (72.78 to 80.12)	77.40% (75.70 to 79.79)	0.794
Normal descending mucosa	80.72% (76.62 to 82.68)	78.38% (76.55 to 80.01)	0.176	77.14% (75.59 to 80.06)	78.59% (76.90 to 79.41)	0.458

ISSN: 1868-7083