Table 2 Median tumor suppressor gene encoded protein scores post- versus pre-decitabine for patients with pre-decitabine scores (≤150), and number of patients with an increase, no change or decrease in scores with decitabine
Protein | n | Score pre-decitabine | Score post-decitabine | P | Number with increase in score | Number with no change in score | Number with decrease in score |
|---|---|---|---|---|---|---|---|
FHIT | 8 | 100 | 175 | 0.014 | 8 | 0 | 0 |
WWOX | 17 | 30 | 100 | 0.05 | 7 | 8 | 2 |
FUS1 | 12 | 67.5 | 100 | 0.07 | 7 | 2 | 3 |
PTEN | 16 | 0 | 0 | 0.20 | 1 | 10 | 5 |
FHIT, WWOX or FUS1 | 37 | 60 | 100 | 0.0002 | 22 | 10 | 5 |