Pharmacokinetic and pharmacodynamic analysis of 5-aza-2’-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy

Table 4 Comparison of methods to determine concentration of 5-AZA-CdR

Method	Limit sensitivity for detection	References
Bioassay	5 nM	[7]
Bioassay	6 nM	[36]
HPLC	750 nM	[90]
HPLC/MS	10 nM	[91]
HPLC/MS	5 nM	[92]

1 μM = 228 ng/ml. 5-AZA-CdR, 5-Aza-2′-deoxycytidine; HPLC, high performance liquid chromatography; HPLC/MS, Hjgh performance liquid chromatography/mass spectrometry.

ISSN: 1868-7083