Figure 1
From: Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy
Overview of the hypoxia inducible factor (HIF) pathway. In normoxic conditions, HIF-1α binds to VHL at specific proline residues leading to ubiquitination and proteosomal degradation. During hypoxia, HIF-1α no longer binds to VHL and accumulates. This leads to formation of the hypoxia response element and subsequent transcription (HIF-1β also known as ARNT (aryl hydrocarbon receptor nuclear translocator), cJUN - jun proto-oncogene, CREB - cAMP responsive element binding protein 1, EP300 - E1A binding protein p300).