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Page 14 of 15

  1. Content type: Case study

    DNA methylation of CpG islands within the promoter region of genes is an epigenetic modification with an important role in the development of cancer and it is typically mediated by DNA methyltransferases (DNMT...

    Authors: Kathrin Kullmann, Mustafa Deryal, Mei Fang Ong, Werner Schmidt and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2013 5:7

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  2. Content type: Research

    Preeclampsia, a pregnancy complication of placental origin is associated with altered expression of angiogenic factors and their receptors. Recently, there is considerable interest in understanding the role of...

    Authors: Deepali P Sundrani, Umakar S Reddy, Asmita A Joshi, Savita S Mehendale, Preeti M Chavan-Gautam, Anandwardhan A Hardikar, Giriraj R Chandak and Sadhana R Joshi

    Citation: Clinical Epigenetics 2013 5:6

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  3. Content type: Reviewer Acknowledgement

    The editors of Clinical Epigenetics would like to thank all our reviewers who have contributed to the journal in volume 4 (2012).

    Authors: Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2013 5:4

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  4. Content type: Review

    5-Aza-2′-deoxycytidine (5-AZA-CdR, decitabine), an epigenetic drug that inhibits DNA methylation, is currently used to treat myelodysplastic syndrome (MDS), and is under investigation for treating acute myeloi...

    Authors: Metin Karahoca and Richard L Momparler

    Citation: Clinical Epigenetics 2013 5:3

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  5. Content type: Research

    Cancer-specific hypermethylation of (promoter) CpG islands is common during the tumorigenesis of colon cancer. Although associations between certain genetic aberrations, such as BRAF mutation and microsatellite i...

    Authors: Eddy H van Roon, Arnoud Boot, Ashwin A Dihal, Robert F Ernst, Tom van Wezel, Hans Morreau and Judith M Boer

    Citation: Clinical Epigenetics 2013 5:2

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  6. Content type: Research

    The occurrence of asthma is weakly explained by known genetic variants. Epigenetic marks, DNA methylation (DNA-M) in particular, are considered to add to the explanation of asthma. However, no etiological mode...

    Authors: Nelís Soto-Ramírez, Syed Hasan Arshad, John W Holloway, Hongmei Zhang, Eric Schauberger, Susan Ewart, Veeresh Patil and Wilfried Karmaus

    Citation: Clinical Epigenetics 2013 5:1

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  7. Content type: Research

    The putative regulatory role of the male reproductive hormones in the molecular mechanism underlying chromatin condensation remains poorly understood. In the past decade, we developed two adult male rat models...

    Authors: Manjeet Kaur Gill-Sharma, Jyoti Choudhuri, Mukhtar Aleem Ansari and Serena D’Souza

    Citation: Clinical Epigenetics 2012 4:23

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  8. Content type: Research

    The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) converts inactive cortisone into active cortisol in insulin target tissues. In people with type 2 diabetes, skeletal muscle (SkM) 11βHSD1 is upregul...

    Authors: Warrick J Inder, Varuni R Obeyesekere, Christina Jang and Richard Saffery

    Citation: Clinical Epigenetics 2012 4:24

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  9. Content type: Methodology

    Studying DNA methylation profiles in detail should be the first step in epigenetic research. Although sodium bisulfite modification of genomic DNA is the gold standard method for DNA methylation analysis, this...

    Authors: Miki Bundo, Fumiko Sunaga, Junko Ueda, Kiyoto Kasai, Tadafumi Kato and Kazuya Iwamoto

    Citation: Clinical Epigenetics 2012 4:22

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  10. Content type: Research

    Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune rheumatic disease of largely unknown cause. Evidence is growing that epigenetic variation, particularly DNA methylation, is associated with autoimmun...

    Authors: Justine A Ellis, Jane E Munro, Raul A Chavez, Lavinia Gordon, Jihoon E Joo, Jonathan D Akikusa, Roger C Allen, Anne-Louise Ponsonby, Jeffrey M Craig and Richard Saffery

    Citation: Clinical Epigenetics 2012 4:20

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  11. Content type: Research

    The insulin-like growth factor 2 (IGF2) and H19 imprinted genes control growth and body composition. Adverse in-utero environments have been associated with obesity-related diseases and linked with altered DNA me...

    Authors: Rae-Chi Huang, John C Galati, Sally Burrows, Lawrence J Beilin, Xin Li, Craig E Pennell, JAM van Eekelen, Trevor A Mori, Leon A Adams and Jeffrey M Craig

    Citation: Clinical Epigenetics 2012 4:21

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  12. Content type: Research

    Oxidative stress may lead to an increased level of unrepaired cellular DNA damage, which is discussed as one risk for tumor initiation. Mismatch repair (MMR) enzymes act as proofreading complexes that maintain...

    Authors: Olivier J Switzeny, Elisabeth Müllner, Karl-Heinz Wagner, Helmut Brath, Eva Aumüller and Alexander G Haslberger

    Citation: Clinical Epigenetics 2012 4:19

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  13. Content type: Research

    Vibration-induced white finger disease (VWF), also known as hand-arm vibration syndrome, is a secondary form of Raynaud’s disease, affecting the blood vessels and nerves. So far, little is known about the path...

    Authors: Susanne Voelter-Mahlknecht, Bernd Rossbach, Christina Schleithoff, Christian L Dransfeld, Stephan Letzel and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2012 4:18

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  14. Content type: Research

    Secondhand smoke (SHS) and ambient air pollution (AAP) exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined t...

    Authors: Arunima Kohli, Marco A Garcia, Rachel L Miller, Christina Maher, Olivier Humblet, S Katharine Hammond and Kari Nadeau

    Citation: Clinical Epigenetics 2012 4:17

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  15. Content type: Research

    MicroRNAs (miRNAs or miRs) are short non-coding RNAs that affect the expression of genes involved in normal physiology, but that also become dysregulated in cancer development. In the latter context, studies t...

    Authors: Mansi A Parasramka, W Mohaiza Dashwood, Rong Wang, Hassaan H Saeed, David E Williams, Emily Ho and Roderick H Dashwood

    Citation: Clinical Epigenetics 2012 4:16

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  16. Content type: Research

    Silver-Russell syndrome (SRS) is characterized by severe intrauterine and postnatal growth failure and frequent body asymmetry. Half of the patients with SRS carry a DNA hypomethylation of the imprinting cente...

    Authors: Kai Kannenberg, Karin Weber, Cathrin Binder, Christina Urban, Hans-Joachim Kirschner and Gerhard Binder

    Citation: Clinical Epigenetics 2012 4:15

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  17. Content type: Hypothesis

    A wet nurse can be used if a baby’s natural mother is unable or chooses not to breastfeed her infant. The practice of using wet nurses is ancient and common to many cultures.

    Authors: Hasan Ozkan, Funda Tuzun, Abdullah Kumral and Nuray Duman

    Citation: Clinical Epigenetics 2012 4:14

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  18. Content type: Research

    Secreted frizzled-related proteins (SFRPs) are antagonists of the Wnt signaling pathway, which plays a central role in stem cell maintenance and differentiation of stem cells and hematopoietic progenitors. Epigen...

    Authors: Karla Bennemann, Oliver Galm, Stefan Wilop, Claudia Schubert, Tim H Brümmendorf and Edgar Jost

    Citation: Clinical Epigenetics 2012 4:12

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  19. Content type: Research

    Epigenetic mechanisms may be involved in the regulation of genes found to be differentially expressed in the visceral adipose tissue (VAT) of severely obese subjects with (MetS+) versus without (MetS-) metabol...

    Authors: Valérie Turcot, André Tchernof, Yves Deshaies, Louis Pérusse, Alexandre Bélisle, Simon Marceau, Simon Biron, Odette Lescelleur, Laurent Biertho and Marie-Claude Vohl

    Citation: Clinical Epigenetics 2012 4:10

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  20. Content type: Research

    It has been suggested that inactivation of p14ARF, a tumor suppressor central to regulating p53 protein stability through interaction with the MDM2 oncoprotein, abrogates p53 activity in human tumors retaining th...

    Authors: Christine Nyiraneza, Christine Sempoux, Roger Detry, Alex Kartheuser and Karin Dahan

    Citation: Clinical Epigenetics 2012 4:9

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  21. Content type: Research

    Birth by cesarean delivery (CD) as opposed to vaginal delivery (VD) is associated with altered health outcomes later in life, including respiratory disorders, allergies and risk of developing type I diabetes. ...

    Authors: Shama Virani, Dana C Dolinoy, Sindhu Halubai, Tamara R Jones, Steve E Domino, Laura S Rozek, Muna S Nahar and Vasantha Padmanabhan

    Citation: Clinical Epigenetics 2012 4:8

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  22. Content type: Review

    Consolidated knowledge is accumulating as to the role of epigenetic regulatory mechanisms in the physiology of vascular development and vascular tone as well as in the pathogenesis of cardiovascular disease. T...

    Authors: Christina Schleithoff, Susanne Voelter-Mahlknecht, Indra Navina Dahmke and Ulrich Mahlknecht

    Citation: Clinical Epigenetics 2012 4:7

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  23. Content type: Review

    The number of children ages 6 to 21 in the United States receiving special education services under the autism disability category increased 91% between 2005 to 2010 while the number of children receiving spec...

    Authors: Renee Dufault, Walter J Lukiw, Raquel Crider, Roseanne Schnoll, David Wallinga and Richard Deth

    Citation: Clinical Epigenetics 2012 4:6

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  24. Content type: Research

    The biological mechanisms responsible for the onset and exacerbation of asthma symptoms in children may involve the epigenetic regulation of inflammatory genes after environmental exposures. Using buccal cells...

    Authors: DZ Torrone, JS Kuriakose, K Moors, H Jiang, MM Niedzwiecki, FF Perera and RL Miller

    Citation: Clinical Epigenetics 2012 4:3

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  25. Content type: Review

    Friedreich ataxia (FRDA) is a debilitating and frequently fatal neurological disorder that is recessively inherited. It belongs to the group of genetic disorders known as the Repeat Expansion Diseases, in whic...

    Authors: Daman Kumari and Karen Usdin

    Citation: Clinical Epigenetics 2012 4:2

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  26. Content type: Review

    Epigenetics is a mechanism that regulates gene expression independently of the underlying DNA sequence, relying instead on the chemical modification of DNA and histone proteins. Although environmental and gene...

    Authors: Takeo Kubota, Kunio Miyake and Takae Hirasawa

    Citation: Clinical Epigenetics 2012 4:1

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  27. Content type: Review

    The influence of epigenetics is evident in many fields of medicine today. This is also true in placentology, where versatile epigenetic mechanisms that regulate expression of genes have shown to have important...

    Authors: L Serman and D Dodig

    Citation: Clinical Epigenetics 2011 3:7

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  28. Content type: Research

    Adenomatous polyposis coli (APC) and Ataxia-telangiectasia-mutated (ATM) gene products have an important role in cell cycle control and maintenance of genomic stability. Our aim was to analyze ATM and APC methyla...

    Authors: Mohammad Ayub Rigi-Ladiz, Dor Mohammad Kordi-Tamandani and Adam Torkamanzehi

    Citation: Clinical Epigenetics 2011 3:6

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  29. Content type: Research

    In utero exposures to environmental factors may result in persistent epigenetic modifications affecting normal development and susceptibility to chronic diseases in later life. We explored the relationship betwee...

    Authors: A Soubry, SK Murphy, Z Huang, A Murtha, JM Schildkraut, RL Jirtle, F Wang, J Kurtzberg, W Demark-Wahnefried, MR Forman and C Hoyo

    Citation: Clinical Epigenetics 2011 3:2

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  30. Content type: Research

    Sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables, induces potent anti-proliferative effects in prostate cancer cells. One mechanism that may contribute to the anti-proliferative effect...

    Authors: Anna Hsu, Carmen P Wong, Zhen Yu, David E Williams, Roderick H Dashwood and Emily Ho

    Citation: Clinical Epigenetics 2011 3:3

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  31. Content type: Original Article

    Epigenetic mechanisms such as DNA hypermethylation and modifications of histone amino acids are known to play an important role in the control of gene expression both in normal human development and tumorigene...

    Authors: Christoph Oing, Edgar Jost, Edgar Dahl, Stefan Wilop, Tim H. Brümmendorf and Oliver Galm

    Citation: Clinical Epigenetics 2011 2:43

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  32. Content type: Review

    This review presents an epigenetic view on complex factors leading to development and perception of “genius.” There is increasing evidence which indicates that artistic creativity is influenced by epigenetic p...

    Authors: Heidrun Karlic and Pia Baurek

    Citation: Clinical Epigenetics 2011 2:33

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  33. Content type: Original Article

    Lymphocytes from the peripheral blood of patients with prostate cancer—the most frequent (noncutaneous) tumor in men—display epigenetic aberrations (altered modes of allelic replication) characteristic of the ...

    Authors: Samuel Cytron, Evgeni Stepnov, Igor Bounkin, Maya Mashevich, Aviva Dotan and Lydia Avivi

    Citation: Clinical Epigenetics 2011 2:29

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  34. Content type: Review

    S100 proteins are small, calcium-binding proteins whose genes are localized in a cluster on human chromosome 1. Through their ability to interact with various protein partners in a calcium-dependent manner, th...

    Authors: Wiesława Leśniak

    Citation: Clinical Epigenetics 2011 2:23

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  35. Content type: Original Article

    Low folate intake is associated with vascular disease. Causality has been attributed to hyperhomocysteinemia. However, human intervention trials have failed to show the benefit of homocysteine-lowering therapi...

    Authors: Chris J. McNeil, John H. Beattie, M-J Gordon, Lynn P. Pirie and Susan J. Duthie

    Citation: Clinical Epigenetics 2011 2:22

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