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  1. Global deregulation of DNA methylation is one of the crucial causes of hepato cellular carcinoma (HCC). It has been reported that the anti-cancer drug 5-azacytidine (5-AZA) mediates the activation of tumor sup...

    Authors: Sahar Olsadat Sajadian, Sabrina Ehnert, Haghighat Vakilian, Eirini Koutsouraki, Georg Damm, Daniel Seehofer, Wolfgang Thasler, Steven Dooley, Hossein Baharvand, Bence Sipos and Andreas K. Nussler

    Citation: Clinical Epigenetics 2015 7:98

    Content type: Research

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  2. A growing body of evidence suggests that the risk of development and progression of a variety of human chronic diseases depends on epigenetic modifications triggered by environmental cues during early life sen...

    Authors: Alexander Vaiserman

    Citation: Clinical Epigenetics 2015 7:96

    Content type: Review

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  3. Scientific data has been transformed into music in order to raise awareness in the non-scientific community. While the general public is nowadays familiar with the genetic code, there is still a lack of knowle...

    Authors: David Brocks

    Citation: Clinical Epigenetics 2015 7:94

    Content type: Letter to the Editor

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  4. Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator...

    Authors: Peter Arner, Indranil Sinha, Anders Thorell, Mikael Rydén, Karin Dahlman-Wright and Ingrid Dahlman

    Citation: Clinical Epigenetics 2015 7:93

    Content type: Research

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  5. Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, pro...

    Authors: Kristina Harrison, Gwen Hoad, Paula Scott, Louise Simpson, Graham W. Horgan, Elizabeth Smyth, Steven D. Heys and Paul Haggarty

    Citation: Clinical Epigenetics 2015 7:92

    Content type: Research

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  6. Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes...

    Authors: Daniel Nätt, Ingela Johansson, Tomas Faresjö, Johnny Ludvigsson and Annika Thorsell

    Citation: Clinical Epigenetics 2015 7:91

    Content type: Research

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  7. 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytosine (5mC) by ten-eleven translocation (Tet) enzymes, has recently drawn attention as the “sixth base” of DNA since it is considered an intermediate o...

    Authors: Keiko Matsubara, Masayo Kagami, Kazuhiko Nakabayashi, Kenichiro Hata, Maki Fukami, Tsutomu Ogata and Kazuki Yamazawa

    Citation: Clinical Epigenetics 2015 7:90

    Content type: Short report

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  8. Silencing of tumor suppressor genes (TSGs) or activation of oncogenes by, e.g., aberrant promoter methylation, may be early events during carcinogenesis. The methylation status of such genes can be used for ea...

    Authors: Imran Nawaz, Khalid Moumad, Debora Martorelli, Moulay Mustapha Ennaji, Xiaoying Zhou, Zhe Zhang, Riccardo Dolcetti, Meriem Khyatti, Ingemar Ernberg and Li-Fu Hu

    Citation: Clinical Epigenetics 2015 7:89

    Content type: Research

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  9. DNA methylation (5-methylcytosine (5mC)) patterns are often altered in cancers. Ten-eleven translocation (Tet) proteins oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytos...

    Authors: Maria Eleftheriou, Ana Jimenez Pascual, Lee M. Wheldon, Christina Perry, Abdulkadir Abakir, Arvind Arora, Andrew D. Johnson, Dorothee T. Auer, Ian O. Ellis, Srinivasan Madhusudan and Alexey Ruzov

    Citation: Clinical Epigenetics 2015 7:88

    Content type: Short Report

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  10. Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes li...

    Authors: Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman and Patricia Fauque

    Citation: Clinical Epigenetics 2015 7:87

    Content type: Review

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  11. Epigenetic alterations, such as aberrant DNA methylation of promoter and enhancer regions, which lead to atypical gene expression, have been associated with carcinogenesis. In hepatocellular carcinoma (HCC), g...

    Authors: Fei Gao, Huifang Liang, Hanlin Lu, Junwen Wang, Meng Xia, Zhimei Yuan, Yu Yao, Tong Wang, Xiaolong Tan, Arian Laurence, Hua Xu, Jingjing Yu, Wei Xiao, Wei Chen, Ming Zhou, Xiuqing Zhang…

    Citation: Clinical Epigenetics 2015 7:86

    Content type: Research

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  12. Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to...

    Authors: Par Bahadur Pun, Yu-Ping Liao, Po-Hsuan Su, Hui-Chen Wang, Yu-Chih Chen, Yaw-Wen Hsu, Rui-Lan Huang, Cheng-Chang Chang and Hung-Cheng Lai

    Citation: Clinical Epigenetics 2015 7:85

    Content type: Research

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  13. Many cancers show aberrant silencing of gene expression and overexpression of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 maintain the repressive chromatin histone methylat...

    Authors: Edward Curry, Ian Green, Nadine Chapman-Rothe, Elham Shamsaei, Sarah Kandil, Fanny L Cherblanc, Luke Payne, Emma Bell, Thota Ganesh, Nitipol Srimongkolpithak, Joachim Caron, Fengling Li, Anthony G. Uren, James P. Snyder, Masoud Vedadi, Matthew J. Fuchter…

    Citation: Clinical Epigenetics 2015 7:84

    Content type: Research

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  14. Deleterious effects of prenatal tobacco smoking on fetal growth and newborn weight are well-established. One of the proposed mechanisms underlying this relationship is alterations in epigenetic programming. We...

    Authors: Marieke I. Bouwland-Both, Nina H. van Mil, Catharina P. Tolhoek, Lisette Stolk, Paul H. C. Eilers, Michael M. P. J. Verbiest, Bastiaan T. Heijmans, André G. Uitterlinden, Albert Hofman, Marinus H. van Ijzendoorn, Liesbeth Duijts, Johan C. de Jongste, Henning Tiemeier, Eric A. P. Steegers, Vincent W. V. Jaddoe and Régine P. M. Steegers-Theunissen

    Citation: Clinical Epigenetics 2015 7:83

    Content type: Research

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  15. Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 hist...

    Authors: Serena Vella, Silvia Pomella, Pier Paolo Leoncini, Marta Colletti, Beatrice Conti, Victor E. Marquez, Antonio Strillacci, Josep Roma, Soledad Gallego, Giuseppe M. Milano, Maurizio C. Capogrossi, Alice Bertaina, Roberta Ciarapica and Rossella Rota

    Citation: Clinical Epigenetics 2015 7:82

    Content type: Research

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  16. Many recent epigenetic studies report that cigarette smoking reduces DNA methylation in whole blood at the single CpG site cg19859270 within the GPR15 gene.

    Authors: Mario Bauer, Gunter Linsel, Beate Fink, Kirsten Offenberg, Anne Maria Hahn, Ulrich Sack, Heike Knaack, Markus Eszlinger and Gunda Herberth

    Citation: Clinical Epigenetics 2015 7:81

    Content type: Research

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  17. Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-r...

    Authors: Valérie Gagné-Ouellet, Simon-Pierre Guay, Anne-Marie Boucher-Lafleur, Luigi Bouchard and Catherine Laprise

    Citation: Clinical Epigenetics 2015 7:80

    Content type: Letter to the Editor

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  18. Gestational diabetes mellitus (GDM) affects approximately 10 % of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be se...

    Authors: Alexandra M. Binder, Jessica LaRocca, Corina Lesseur, Carmen J. Marsit and Karin B. Michels

    Citation: Clinical Epigenetics 2015 7:79

    Content type: Research

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  19. Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obta...

    Authors: Karin van Veldhoven, Silvia Polidoro, Laura Baglietto, Gianluca Severi, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Domenico Palli, Giovanna Masala, Vittorio Krogh, Claudia Agnoli, Rosario Tumino, Graziella Frasca, Kirsty Flower, Ed Curry, Nicholas Orr…

    Citation: Clinical Epigenetics 2015 7:67

    Content type: Research

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  20. DNA methylation is a heritable and stable epigenetic mark implicated in complex human traits. Epigenome-wide association studies (EWAS) using array-based technology are becoming widely used to identify differe...

    Authors: Cristina Gallego-Fabrega, Caty Carrera, Elena Muiño, Joan Montaner, Jurek Krupinski and Israel Fernandez-Cadenas

    Citation: Clinical Epigenetics 2015 7:78

    Content type: Methodology

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  21. Anaplasma phagocytophilum is an obligate intracellular prokaryotic pathogen that both infects and replicates within human neutrophils. The bacterium represses multiple antimicrobial fu...

    Authors: Sara H. G. Sinclair, Srinivasan Yegnasubramanian and J. Stephen Dumler

    Citation: Clinical Epigenetics 2015 7:77

    Content type: Research

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  22. Abnormal sex chromosome numbers in humans are observed in Turner (45,X) and Klinefelter (47,XXY) syndromes. Both syndromes are associated with several clinical phenotypes, whose molecular mechanisms are obscur...

    Authors: Amit Sharma, Muhammad Ahmer Jamil, Nicole Nuesgen, Felix Schreiner, Lutz Priebe, Per Hoffmann, Stefan Herns, Markus M. Nöthen, Holger Fröhlich, Johannes Oldenburg, Joachim Woelfle and Osman El-Maarri

    Citation: Clinical Epigenetics 2015 7:76

    Content type: Research

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  23. Ductal carcinoma in situ (DCIS) is a heterogeneous, pre-invasive lesion associated with an increased risk for future invasive ductal carcinoma. However, accurate risk stratification for development of invasive...

    Authors: Kevin C. Johnson, Devin C. Koestler, Thomas Fleischer, Panpan Chen, Erik G. Jenson, Jonathan D. Marotti, Tracy Onega, Vessela N. Kristensen and Brock C. Christensen

    Citation: Clinical Epigenetics 2015 7:75

    Content type: Research

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  24. Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the accumulation of pro-inflammatory signals, which constitutes a hallmark of cancer. To...

    Authors: Inês Cebola, Joaquin Custodio, Mar Muñoz, Anna Díez-Villanueva, Laia Paré, Patricia Prieto, Susanna Aussó, Llorenç Coll-Mulet, Lisardo Boscá, Victor Moreno and Miguel A. Peinado

    Citation: Clinical Epigenetics 2015 7:74

    Content type: Research

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  25. The gene expressions of netrin-1 dependence receptors, DCC and UNC5C, are frequently downregulated in many cancers. We hypothesized that downregulation of DCC and UNC5C has an important growth regulatory function...

    Authors: Keisuke Toda, Takeshi Nagasaka, Yuzo Umeda, Takehiro Tanaka, Takashi Kawai, Tomokazu Fuji, Fumitaka Taniguchi, Kazuya Yasui, Nobuhito Kubota, Yuko Takehara, Hiroshi Tazawa, Shunsuke Kagawa, Dong-Sheng Sun, Naoshi Nishida, Ajay Goel and Toshiyoshi Fujiwara

    Citation: Clinical Epigenetics 2015 7:73

    Content type: Research

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  26. Aging is a complex phenomenon and characterized by a progressive decline in physiology and function of adult tissues. However, it hasn’t been well established of the correlation between aging and global DNA me...

    Authors: Jun Xiong, Han-Peng Jiang, Chun-Yan Peng, Qian-Yun Deng, Meng-Dan Lan, Huan Zeng, Fang Zheng, Yu-Qi Feng and Bi-Feng Yuan

    Citation: Clinical Epigenetics 2015 7:72

    Content type: Research

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  27. Lynch syndrome (LS) is associated with germline mutations in DNA mismatch repair (MMR) genes. The first “hit” to inactivate one allele of the predisposing MMR gene is present in every cell, contributing to acc...

    Authors: Satu Valo, Sippy Kaur, Ari Ristimäki, Laura Renkonen-Sinisalo, Heikki Järvinen, Jukka-Pekka Mecklin, Minna Nyström and Päivi Peltomäki

    Citation: Clinical Epigenetics 2015 7:71

    Content type: Research

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  28. There is much debate around the preoperative treatment of colorectal cancer and, in particular, neoadjuvant chemoradiotherapy in locally advanced rectal cancer. This treatment carries a significant risk of har...

    Authors: Jeremy S. Williamson, Dean A. Harris, John Beynon and Gareth J.S. Jenkins

    Citation: Clinical Epigenetics 2015 7:70

    Content type: Review

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  29. Depressive/anxiety disorders are the most common types of mental illnesses in the world. The present study was the first to explore the association between plasma microRNAs (miRNAs) and depression/anxiety in p...

    Authors: Xiao Wang, Kristina Sundquist, Anna Hedelius, Karolina Palmér, Ashfaque A. Memon and Jan Sundquist

    Citation: Clinical Epigenetics 2015 7:69

    Content type: Research

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  30. The prevalence of eczema is increasing in industrialized nations. Limited evidence has shown the association of DNA methylation (DNA-M) with eczema. We explored this association at the epigenome-scale to bette...

    Authors: B. M. Quraishi, H. Zhang, T. M. Everson, M. Ray, G. A. Lockett, J. W. Holloway, S. R. Tetali, S. H. Arshad, A. Kaushal, F. I. Rezwan and W. Karmaus

    Citation: Clinical Epigenetics 2015 7:68

    Content type: Research

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  31. The increased prevalence of obesity and related comorbidities is a major public health problem. While genetic factors undoubtedly play a role in determining individual susceptibility to weight gain and obesity...

    Authors: Susan J. van Dijk, Ross L. Tellam, Janna L. Morrison, Beverly S. Muhlhausler and Peter L. Molloy

    Citation: Clinical Epigenetics 2015 7:66

    Content type: Review

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  32. Aberrant epigenetic modifications are described in an increasing number of pathological conditions, including neurodegenerative diseases, cardiovascular diseases, diabetes mellitus type 2, obesity and cancer. ...

    Authors: Christian Busch, Markus Burkard, Christian Leischner, Ulrich M. Lauer, Jan Frank and Sascha Venturelli

    Citation: Clinical Epigenetics 2015 7:64

    Content type: Review

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  33. Profound methylation of CpG islands constitutes a distinct molecular subtype of colorectal cancer (CRC). The frequencies of methylation in CRC vary according to clinico-pathological characteristics including s...

    Authors: Dae-Won Lee, Sae-Won Han, Yongjun Cha, Ye Young Rhee, Jeong Mo Bae, Nam-Yun Cho, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang and Tae-You Kim

    Citation: Clinical Epigenetics 2015 7:63

    Content type: Research

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  34. Classification of pediatric tumors into biologically defined subtypes is challenging, and multifaceted approaches are needed. For this aim, we developed a diagnostic classifier based on DNA methylation profiles.

    Authors: Anna Danielsson, Szilárd Nemes, Magnus Tisell, Birgitta Lannering, Claes Nordborg, Magnus Sabel and Helena Carén

    Citation: Clinical Epigenetics 2015 7:62

    Content type: Methodology

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  35. Although the etiology of primary biliary cirrhosis (PBC) remains enigmatic, there are several pieces of data supporting the thesis that a strong genetic predisposition and environmental factors interact to pro...

    Authors: Ana Lleo, Weici Zhang, Ming Zhao, Yixin Tan, Francesca Bernuzzi, Bochen Zhu, Qian Liu, Qiqun Tan, Federica Malinverno, Luca Valenti, Tingting Jiang, Lina Tan, Wei Liao, Ross Coppel, Pietro Invernizzi, Qianjin Lu…

    Citation: Clinical Epigenetics 2015 7:61

    Content type: Research

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  36. Mitochondrial alterations have been observed in subjects with metabolic disorders such as obesity and diabetes. Studies on animal models and cell cultures suggest aberrant glucose and lipid levels, and impaire...

    Authors: Louise D. Zheng, Leah E. Linarelli, Longhua Liu, Sarah S. Wall, Mark H. Greenawald, Richard W. Seidel, Paul A. Estabrooks, Fabio A. Almeida and Zhiyong Cheng

    Citation: Clinical Epigenetics 2015 7:60

    Content type: Research

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  37. Recent developments in genomic sequencing have advanced our understanding of the mutations underlying human malignancy. Melanoma is a prototype of an aggressive, genetically heterogeneous cancer notorious for ...

    Authors: Jonathan J. Lee, Lynette M. Sholl, Neal I. Lindeman, Scott R. Granter, Alvaro C. Laga, Priyanka Shivdasani, Gary Chin, Jason J. Luke, Patrick A. Ott, F. Stephen Hodi, Martin C. Mihm Jr., Jennifer Y. Lin, Andrew E. Werchniak, Harley A. Haynes, Nancy Bailey, Robert Liu…

    Citation: Clinical Epigenetics 2015 7:59

    Content type: Research

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  38. Carboplatin/paclitaxel (CP), with or without sorafenib, result in objective response rates of 18–20 % in unselected chemotherapy-naïve patients. Molecular predictors of survival and response to CP-based chemot...

    Authors: Liza C. Villaruz, Grace Huang, Marjorie Romkes, John M. Kirkwood, Shama C. Buch, Tomoko Nukui, Keith T. Flaherty, Sandra J. Lee, Melissa A. Wilson, Katherine L. Nathanson, Panayiotis V. Benos and Hussein A. Tawbi

    Citation: Clinical Epigenetics 2015 7:58

    Content type: Research

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  39. Tumour metastasis to the brain is a common and deadly development in certain cancers; 18–30 % of breast tumours metastasise to the brain. The contribution that gene silencing through epigenetic mechanisms play...

    Authors: Rajendra P. Pangeni, Prasanna Channathodiyil, David S. Huen, Lawrence W. Eagles, Balraj K. Johal, Dawar Pasha, Natasa Hadjistephanou, Oliver Nevell, Claire L. Davies, Ayobami I. Adewumi, Hamida Khanom, Ikroop S. Samra, Vanessa C. Buzatto, Preethi Chandrasekaran, Thoraia Shinawi, Timothy P. Dawson…

    Citation: Clinical Epigenetics 2015 7:57

    Content type: Research

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  40. The development of type-2 diabetes mellitus (T2DM) and its complications is largely due to the complex interaction between genetic factors and environmental influences, mainly dietary habits and lifestyle, whi...

    Authors: Francesco Prattichizzo, Angelica Giuliani, Artan Ceka, Maria Rita Rippo, Anna Rita Bonfigli, Roberto Testa, Antonio Domenico Procopio and Fabiola Olivieri

    Citation: Clinical Epigenetics 2015 7:56

    Content type: Review

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  41. Tobacco smoking, a risk factor for coronary artery disease (CAD), is known to modify DNA methylation. We hypothesized that tobacco smoking modifies methylation of the genes identified for CAD by genome-wide as...

    Authors: Rebecca V Steenaard, Symen Ligthart, Lisette Stolk, Marjolein J Peters, Joyce B van Meurs, Andre G Uitterlinden, Albert Hofman, Oscar H Franco and Abbas Dehghan

    Citation: Clinical Epigenetics 2015 7:54

    Content type: Research

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  42. Dysregulation of the epigenome is a common event in malignancy; however, deciphering the earliest cancer-associated epigenetic events remains a challenge. Cancer epigenome studies to date have primarily utilis...

    Authors: Warwick J Locke, Elena Zotenko, Clare Stirzaker, Mark D Robinson, Rebecca A Hinshelwood, Andrew Stone, Roger R Reddel, Lily I Huschtscha and Susan J Clark

    Citation: Clinical Epigenetics 2015 7:52

    Content type: Research

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  43. Current evidence supports the notion that environmental exposures are associated with DNA-methylation and expression changes that can impact human health. Our objective was to conduct a systematic review of ep...

    Authors: Adrian Ruiz-Hernandez, Chin-Chi Kuo, Pilar Rentero-Garrido, Wan-Yee Tang, Josep Redon, Jose M Ordovas, Ana Navas-Acien and Maria Tellez-Plaza

    Citation: Clinical Epigenetics 2015 7:55

    Content type: Review

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  44. The loss of 5-hydroxymethylcytosine (5hmC) has been identified as a novel epigenetic hallmark for melanoma. One of the known mechanisms underlying the loss of 5hmC is the decrease in expression of ten-eleven t...

    Authors: Christopher B Gustafson, Cuixia Yang, Kevin M Dickson, Hongwei Shao, Derek Van Booven, J William Harbour, Zhao-Jun Liu and Gaofeng Wang

    Citation: Clinical Epigenetics 2015 7:51

    Content type: Research

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  45. The interpretation of equivocal Papanicolaou (Pap) smear results remains challenging, even with the addition of the high-risk human papillomavirus test (HPV-HR). Recently, methylated zinc finger protein 582 (ZNF5...

    Authors: Yu-Ligh Liou, Yu Zhang, Yingzi Liu, Lanqin Cao, Chong-Zhen Qin, Tao-Lan Zhang, Chi-Feng Chang, Huei-Jen Wang, Shu-Yi Lin, Tang-Yuan Chu, Yi Zhang and Hong-Hao Zhou

    Citation: Clinical Epigenetics 2015 7:50

    Content type: Case study

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  46. The relevance of microRNAs (miRNAs) in adipose tissue is increasingly recognized, being intrinsically linked to different pathways, including obesity-related inflammation. In this study, we aimed to characteri...

    Authors: Francisco José Ortega, María Moreno, Josep María Mercader, José María Moreno-Navarrete, Núria Fuentes-Batllevell, Mònica Sabater, Wifredo Ricart and José Manuel Fernández-Real

    Citation: Clinical Epigenetics 2015 7:49

    Content type: Research

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  47. The Illumina Infinium HumanMethylation450 BeadChip is an array-based technology for analysing DNA methylation at approximately 475,000 differentially methylated cytosines across the human genome. Hitherto, the...

    Authors: Faisal I Rezwan, Louise E Docherty, Rebecca L Poole, Gabrielle A Lockett, S Hasan Arshad, John W Holloway, I Karen Temple and Deborah JG Mackay

    Citation: Clinical Epigenetics 2015 7:48

    Content type: Methodology

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  48. The birth weight of Black neonates in the United States is consistently smaller than that of their White counterparts. Epigenetic differences between the races may be involved in such disparities. The goal of ...

    Authors: Jennifer K Straughen, Levent Sipahi, Monica Uddin, Dawn P Misra and Vinod K Misra

    Citation: Clinical Epigenetics 2015 7:47

    Content type: Research

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