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  1. Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years...

    Authors: Thomas Eggermann, Guiomar Perez de Nanclares, Eamonn R. Maher, I. Karen Temple, Zeynep Tümer, David Monk, Deborah J. G. Mackay, Karen Grønskov, Andrea Riccio, Agnès Linglart and Irène Netchine

    Citation: Clinical Epigenetics 2015 7:123

    Content type: Review

    Published on:

    The Erratum to this article has been published in Clinical Epigenetics 2016 8:27

  2. Stressor exposure during early life has the potential to increase an individual’s susceptibility to a number of neuropsychiatric conditions such as mood and anxiety disorders and schizophrenia in adulthood. Th...

    Authors: Magdalene C. Jawahar, Chris Murgatroyd, Emma L. Harrison and Bernhard T. Baune

    Citation: Clinical Epigenetics 2015 7:122

    Content type: Review

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  3. The correlation between epigenetics and human reproduction represents a very interesting field of study, mainly due to the possible transgenerational effects related to epigenetic modifications of male and fem...

    Authors: Liborio Stuppia, Marica Franzago, Patrizia Ballerini, Valentina Gatta and Ivana Antonucci

    Citation: Clinical Epigenetics 2015 7:120

    Content type: Review

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  4. The Response Evaluation Criteria in Solid Tumors (RECIST) guideline and Common Terminology Criteria for Adverse Events (CTCAE) criteria are used to assess chemotherapy efficiency and toxicity in patients with ...

    Authors: Hong Wang, Bingfeng Zhang, Dan Chen, Wenying Xia, Jiexin Zhang, Fang Wang, Jian Xu, Yan Zhang, Meijuan Zhang, Lixia Zhang, Yachun Lu, Yan Geng, Peijun Huang, Puwen Huang, Hong Wang and Shiyang Pan

    Citation: Clinical Epigenetics 2015 7:119

    Content type: Research

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  5. Multiple sclerosis (MS) is thought to be a T cell-mediated autoimmune disorder. MS pathogenesis is likely due to a genetic predisposition triggered by a variety of environmental factors. Epigenetics, particula...

    Authors: Vicki E. Maltby, Moira C. Graves, Rodney A. Lea, Miles C. Benton, Katherine A. Sanders, Lotti Tajouri, Rodney J. Scott and Jeannette Lechner-Scott

    Citation: Clinical Epigenetics 2015 7:118

    Content type: Short report

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  6. Acute lymphoblastic leukemia (ALL) has been generally considered a genetic disease (disorder) with an aggressive tumor entity of highly proliferative malignant lymphoid cells. However, in recent years, signifi...

    Authors: Cheng Zhang, Jiang F. Zhong, Andres Stucky, Xue-Lian Chen, Michael F. Press and Xi Zhang

    Citation: Clinical Epigenetics 2015 7:117

    Content type: Review

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  7. Epigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation (DNAm) patterns can be used for classific...

    Authors: Tanja Božić, Qiong Lin, Joana Frobel, Stefan Wilop, Melanie Hoffmann, Carsten Müller-Tidow, Tim H. Brümmendorf, Edgar Jost and Wolfgang Wagner

    Citation: Clinical Epigenetics 2015 7:116

    Content type: Short report

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  8. Peroxisome proliferator-activated receptor gamma (PPAR-γ) has been demonstrated to be involved in anti-inflammatory reactions, but its role in acute-on-chronic hepatitis B liver failure (ACHBLF) is unclear. Th...

    Authors: Ze-Hua Zhao, Yu-Chen Fan, Qi Zhao, Cheng-Yun Dou, Xiang-Fen Ji, Jing Zhao, Shuai Gao, Xin-You Li and Kai Wang

    Citation: Clinical Epigenetics 2015 7:115

    Content type: Research

    Published on:

  9. Many human tumors show aberrant activation of a group of germline-specific genes, termed cancer-germline (CG) genes, several of which appear to exert oncogenic functions. Although activation of CG genes in tum...

    Authors: Julie Cannuyer, Aurélie Van Tongelen, Axelle Loriot and Charles De Smet

    Citation: Clinical Epigenetics 2015 7:114

    Content type: Research

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  10. Active smoking is a major preventable public health problem and an established critical factor for epigenetic modification. In this systematic review, we identified 17 studies addressing the association of act...

    Authors: Xu Gao, Min Jia, Yan Zhang, Lutz Philipp Breitling and Hermann Brenner

    Citation: Clinical Epigenetics 2015 7:113

    Content type: Review

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  11. Epigenetic modulation of gene activity occurs in response to non-genetic factors such as body weight status, physical activity, dietary factors, and environmental toxins. In addition, each of these factors is ...

    Authors: Bidisha Paul, Stephen Barnes, Wendy Demark-Wahnefried, Casey Morrow, Carolina Salvador, Christine Skibola and Trygve O. Tollefsbol

    Citation: Clinical Epigenetics 2015 7:112

    Content type: Review

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  12. Prostate cancer (PC) can be stratified into distinct molecular subtypes based on TMPRSS2-ERG gene fusion status, but its potential prognostic value remains controversial. Likewise, routine clinicopathological fea...

    Authors: Siri H. Strand, Soren Hoyer, Anne-Sofie Lynnerup, Christa Haldrup, Tine Maj Storebjerg, Michael Borre, Torben F. Orntoft and Karina D. Sorensen

    Citation: Clinical Epigenetics 2015 7:111

    Content type: Research

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  13. Aberrant DNA methylation at imprinted loci is an important molecular mechanism contributing to several developmental and pathological disorders including cancer. However, knowledge about imprinting defects due...

    Authors: Sumadi Lukman Anwar, Till Krech, Britta Hasemeier, Elisa Schipper, Nora Schweitzer, Arndt Vogel, Hans Kreipe and Ulrich Lehmann

    Citation: Clinical Epigenetics 2015 7:110

    Content type: Research

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  14. Long non-coding RNAs (lncRNAs) have been claimed as key molecular players in gene expression regulation, being involved in diverse epigenetic processes. They are aberrantly expressed in various tumors, but the...

    Authors: Mónica Martínez-Fernández, Andrew Feber, Marta Dueñas, Cristina Segovia, Carolina Rubio, Maria Fernandez, Felipe Villacampa, José Duarte, Fernando F. López-Calderón, Ma José Gómez-Rodriguez, Daniel Castellano, Jose L. Rodriguez-Peralto, Federico de la Rosa, Stephan Beck and Jesús M. Paramio

    Citation: Clinical Epigenetics 2015 7:109

    Content type: Short report

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  15. Given the implication of histone acetylation in memory processes, histone deacetylase inhibitors (HDACIs) have been postulated as potential modulators of cognitive impairment in Alzheimer’s disease (AD). Howev...

    Authors: M. Cuadrado-Tejedor, C. Garcia-Barroso, J. Sanzhez-Arias, S. Mederos, O. Rabal, A. Ugarte, R. Franco, M. Pascual-Lucas, V. Segura, G. Perea, J. Oyarzabal and A. Garcia-Osta

    Citation: Clinical Epigenetics 2015 7:108

    Content type: Research

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  16. Subtelomeric regions dynamically change their epigenetic pattern during development and progression of several malignancies and degenerative disorders. However, DNA methylation of human subtelomeres and their ...

    Authors: Samrat Roy Choudhury, Yi Cui, Jacob R. Milton, Jian Li and Joseph Irudayaraj

    Citation: Clinical Epigenetics 2015 7:107

    Content type: Research

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  17. To improve the prognosis of patients with pancreatic cancer, new biomarkers are required for earlier, pre-symptomatic diagnosis. Epigenetic mutations take place at the earliest stages of tumorigenesis and ther...

    Authors: Monika Bauden, Dorian Pamart, Daniel Ansari, Marielle Herzog, Mark Eccleston, Jake Micallef, Bodil Andersson and Roland Andersson

    Citation: Clinical Epigenetics 2015 7:106

    Content type: Research

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  18. Drug metabolizing enzymes (DMEs) exhibit dramatic inter- and intra-individual variability in expression and activity. However, the mechanisms determining this variability have not been fully elucidated. The ai...

    Authors: Wataru Habano, Kohei Kawamura, Natsuki Iizuka, Jun Terashima, Tamotsu Sugai and Shogo Ozawa

    Citation: Clinical Epigenetics 2015 7:105

    Content type: Research

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  19. CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. It usually occurs at early steps of cancer progression and can be detected easily,...

    Authors: Nilufer Sayar, Gurbet Karahan, Ozlen Konu, Betul Bozkurt, Onder Bozdogan and Isik G. Yulug

    Citation: Clinical Epigenetics 2015 7:104

    Content type: Research

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  20. The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The cur...

    Authors: Praveen Rajendran, Wan-Mohaiza Dashwood, Li Li, Yuki Kang, Eunah Kim, Gavin Johnson, Kay A. Fischer, Christiane V. Löhr, David E. Williams, Emily Ho, Masayuki Yamamoto, David A. Lieberman and Roderick H. Dashwood

    Citation: Clinical Epigenetics 2015 7:102

    Content type: Research

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  21. Serrated adenocarcinoma (SAC) is a recently recognized colorectal cancer (CRC) subtype accounting for 7.5–8.7 % of CRCs. It has been shown that SAC has a worse prognosis and different histological and molecula...

    Authors: Pablo Conesa-Zamora, José García-Solano, María del Carmen Turpin, Patricia Sebastián-León, Daniel Torres-Moreno, Eduardo Estrada, Anne Tuomisto, Jamie Wilce, Markus J. Mäkinen, Miguel Pérez-Guillermo and Ana Conesa

    Citation: Clinical Epigenetics 2015 7:101

    Content type: Research

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  22. A number of clinico-pathological criteria and molecular profiles have been used to stratify patients into high- and low-risk groups. Currently, there are still no effective methods to determine which patients ...

    Authors: Christophe Legendre, Gerald C. Gooden, Kyle Johnson, Rae Anne Martinez, Winnie S. Liang and Bodour Salhia

    Citation: Clinical Epigenetics 2015 7:100

    Content type: Research

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  23. The vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) signaling pathway is involved in cancer-related biological functions and is a therapeutic target in cancer. However, the influence of epigene...

    Authors: Jee Yeon Kim, Junha Hwang, Seo Hyun Lee, Hyo Jin Lee, Jaroslav Jelinek, Hyeseon Jeong, Jae Sung Lim, Jin Man Kim, Kyu Sang Song, Byung Hoon Kim, Sukhoon Lee and Jei Kim

    Citation: Clinical Epigenetics 2015 7:99

    Content type: Research

    Published on:

  24. Global deregulation of DNA methylation is one of the crucial causes of hepato cellular carcinoma (HCC). It has been reported that the anti-cancer drug 5-azacytidine (5-AZA) mediates the activation of tumor sup...

    Authors: Sahar Olsadat Sajadian, Sabrina Ehnert, Haghighat Vakilian, Eirini Koutsouraki, Georg Damm, Daniel Seehofer, Wolfgang Thasler, Steven Dooley, Hossein Baharvand, Bence Sipos and Andreas K. Nussler

    Citation: Clinical Epigenetics 2015 7:98

    Content type: Research

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  25. Aberrant epigenetic silencing of tumor suppressor genes has been recognized as a driving force in cancer. Epigenetic drugs such as the DNA methylation inhibitor decitabine reactivate genes and are effective in...

    Authors: Taichun Qin, Jiali Si, Noël J-M Raynal, Xiaodan Wang, Vazganush Gharibyan, Saira Ahmed, Xin Hu, Chunlei Jin, Yue Lu, Jingmin Shu, Marcos RH Estecio, Jaroslav Jelinek and Jean-Pierre J. Issa

    Citation: Clinical Epigenetics 2015 7:97

    Content type: Research

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  26. A growing body of evidence suggests that the risk of development and progression of a variety of human chronic diseases depends on epigenetic modifications triggered by environmental cues during early life sen...

    Authors: Alexander Vaiserman

    Citation: Clinical Epigenetics 2015 7:96

    Content type: Review

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  27. Genome-wide DNA methylation (DNAm) studies have proven extremely useful to understand human hematopoiesis. Due to their active DNA content, nucleated red blood cells (nRBCs) contribute to epigenetic and transc...

    Authors: Olivia M. de Goede, Hamid R. Razzaghian, E. Magda Price, Meaghan J. Jones, Michael S. Kobor, Wendy P. Robinson and Pascal M. Lavoie

    Citation: Clinical Epigenetics 2015 7:95

    Content type: Research

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  28. Scientific data has been transformed into music in order to raise awareness in the non-scientific community. While the general public is nowadays familiar with the genetic code, there is still a lack of knowle...

    Authors: David Brocks

    Citation: Clinical Epigenetics 2015 7:94

    Content type: Letter to the Editor

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  29. Obesity is associated with changes in fat cell gene expression and metabolism. What drives these changes is not well understood. We aimed to explore fat cell epigenetics, i.e., DNA methylation, as one mediator...

    Authors: Peter Arner, Indranil Sinha, Anders Thorell, Mikael Rydén, Karin Dahlman-Wright and Ingrid Dahlman

    Citation: Clinical Epigenetics 2015 7:93

    Content type: Research

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  30. Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, pro...

    Authors: Kristina Harrison, Gwen Hoad, Paula Scott, Louise Simpson, Graham W. Horgan, Elizabeth Smyth, Steven D. Heys and Paul Haggarty

    Citation: Clinical Epigenetics 2015 7:92

    Content type: Research

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  31. Childhood stress leads to increased risk of many adult diseases, such as major depression and cardiovascular disease. Studies show that adults with experienced childhood stress have specific epigenetic changes...

    Authors: Daniel Nätt, Ingela Johansson, Tomas Faresjö, Johnny Ludvigsson and Annika Thorsell

    Citation: Clinical Epigenetics 2015 7:91

    Content type: Research

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  32. 5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytosine (5mC) by ten-eleven translocation (Tet) enzymes, has recently drawn attention as the “sixth base” of DNA since it is considered an intermediate o...

    Authors: Keiko Matsubara, Masayo Kagami, Kazuhiko Nakabayashi, Kenichiro Hata, Maki Fukami, Tsutomu Ogata and Kazuki Yamazawa

    Citation: Clinical Epigenetics 2015 7:90

    Content type: Short report

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  33. Silencing of tumor suppressor genes (TSGs) or activation of oncogenes by, e.g., aberrant promoter methylation, may be early events during carcinogenesis. The methylation status of such genes can be used for ea...

    Authors: Imran Nawaz, Khalid Moumad, Debora Martorelli, Moulay Mustapha Ennaji, Xiaoying Zhou, Zhe Zhang, Riccardo Dolcetti, Meriem Khyatti, Ingemar Ernberg and Li-Fu Hu

    Citation: Clinical Epigenetics 2015 7:89

    Content type: Research

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  34. DNA methylation (5-methylcytosine (5mC)) patterns are often altered in cancers. Ten-eleven translocation (Tet) proteins oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytos...

    Authors: Maria Eleftheriou, Ana Jimenez Pascual, Lee M. Wheldon, Christina Perry, Abdulkadir Abakir, Arvind Arora, Andrew D. Johnson, Dorothee T. Auer, Ian O. Ellis, Srinivasan Madhusudan and Alexey Ruzov

    Citation: Clinical Epigenetics 2015 7:88

    Content type: Short Report

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  35. Today, there is growing interest in the potential epigenetic risk related to assisted reproductive technologies (ART). Much evidence in the literature supports the hypothesis that adverse pregnancy outcomes li...

    Authors: Cécile Choux, Virginie Carmignac, Céline Bruno, Paul Sagot, Daniel Vaiman and Patricia Fauque

    Citation: Clinical Epigenetics 2015 7:87

    Content type: Review

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  36. Epigenetic alterations, such as aberrant DNA methylation of promoter and enhancer regions, which lead to atypical gene expression, have been associated with carcinogenesis. In hepatocellular carcinoma (HCC), g...

    Authors: Fei Gao, Huifang Liang, Hanlin Lu, Junwen Wang, Meng Xia, Zhimei Yuan, Yu Yao, Tong Wang, Xiaolong Tan, Arian Laurence, Hua Xu, Jingjing Yu, Wei Xiao, Wei Chen, Ming Zhou, Xiuqing Zhang…

    Citation: Clinical Epigenetics 2015 7:86

    Content type: Research

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  37. Insufficient specificity of the high-risk human papillomavirus (hrHPV) assay in primary cervical cancer screening results in unnecessary referral. Additional assays to triage hrHPV-positive women are needed to...

    Authors: Par Bahadur Pun, Yu-Ping Liao, Po-Hsuan Su, Hui-Chen Wang, Yu-Chih Chen, Yaw-Wen Hsu, Rui-Lan Huang, Cheng-Chang Chang and Hung-Cheng Lai

    Citation: Clinical Epigenetics 2015 7:85

    Content type: Research

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  38. Many cancers show aberrant silencing of gene expression and overexpression of histone methyltransferases. The histone methyltransferases (HKMT) EZH2 and EHMT2 maintain the repressive chromatin histone methylat...

    Authors: Edward Curry, Ian Green, Nadine Chapman-Rothe, Elham Shamsaei, Sarah Kandil, Fanny L Cherblanc, Luke Payne, Emma Bell, Thota Ganesh, Nitipol Srimongkolpithak, Joachim Caron, Fengling Li, Anthony G. Uren, James P. Snyder, Masoud Vedadi, Matthew J. Fuchter…

    Citation: Clinical Epigenetics 2015 7:84

    Content type: Research

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  39. Deleterious effects of prenatal tobacco smoking on fetal growth and newborn weight are well-established. One of the proposed mechanisms underlying this relationship is alterations in epigenetic programming. We...

    Authors: Marieke I. Bouwland-Both, Nina H. van Mil, Catharina P. Tolhoek, Lisette Stolk, Paul H. C. Eilers, Michael M. P. J. Verbiest, Bastiaan T. Heijmans, André G. Uitterlinden, Albert Hofman, Marinus H. van Ijzendoorn, Liesbeth Duijts, Johan C. de Jongste, Henning Tiemeier, Eric A. P. Steegers, Vincent W. V. Jaddoe and Régine P. M. Steegers-Theunissen

    Citation: Clinical Epigenetics 2015 7:83

    Content type: Research

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  40. Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma arising from myogenic precursors that have lost their capability to differentiate into skeletal muscle. The polycomb-group protein EZH2 is a Lys27 hist...

    Authors: Serena Vella, Silvia Pomella, Pier Paolo Leoncini, Marta Colletti, Beatrice Conti, Victor E. Marquez, Antonio Strillacci, Josep Roma, Soledad Gallego, Giuseppe M. Milano, Maurizio C. Capogrossi, Alice Bertaina, Roberta Ciarapica and Rossella Rota

    Citation: Clinical Epigenetics 2015 7:82

    Content type: Research

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  41. Many recent epigenetic studies report that cigarette smoking reduces DNA methylation in whole blood at the single CpG site cg19859270 within the GPR15 gene.

    Authors: Mario Bauer, Gunter Linsel, Beate Fink, Kirsten Offenberg, Anne Maria Hahn, Ulrich Sack, Heike Knaack, Markus Eszlinger and Gunda Herberth

    Citation: Clinical Epigenetics 2015 7:81

    Content type: Research

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  42. Interleukin 1 and its receptors are associated with allergic diseases such as asthma. In the present study, we measured DNA methylation at the IL1R1 and IL1R2 gene loci and assessed for associations with asthma-r...

    Authors: Valérie Gagné-Ouellet, Simon-Pierre Guay, Anne-Marie Boucher-Lafleur, Luigi Bouchard and Catherine Laprise

    Citation: Clinical Epigenetics 2015 7:80

    Content type: Letter to the Editor

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  43. Gestational diabetes mellitus (GDM) affects approximately 10 % of pregnancies in the United States and increases the risk of adverse health outcomes in the offspring. These adult disease propensities may be se...

    Authors: Alexandra M. Binder, Jessica LaRocca, Corina Lesseur, Carmen J. Marsit and Karin B. Michels

    Citation: Clinical Epigenetics 2015 7:79

    Content type: Research

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  44. Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obta...

    Authors: Karin van Veldhoven, Silvia Polidoro, Laura Baglietto, Gianluca Severi, Carlotta Sacerdote, Salvatore Panico, Amalia Mattiello, Domenico Palli, Giovanna Masala, Vittorio Krogh, Claudia Agnoli, Rosario Tumino, Graziella Frasca, Kirsty Flower, Ed Curry, Nicholas Orr…

    Citation: Clinical Epigenetics 2015 7:67

    Content type: Research

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  45. DNA methylation is a heritable and stable epigenetic mark implicated in complex human traits. Epigenome-wide association studies (EWAS) using array-based technology are becoming widely used to identify differe...

    Authors: Cristina Gallego-Fabrega, Caty Carrera, Elena Muiño, Joan Montaner, Jurek Krupinski and Israel Fernandez-Cadenas

    Citation: Clinical Epigenetics 2015 7:78

    Content type: Methodology

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  46. Anaplasma phagocytophilum is an obligate intracellular prokaryotic pathogen that both infects and replicates within human neutrophils. The bacterium represses multiple antimicrobial fu...

    Authors: Sara H. G. Sinclair, Srinivasan Yegnasubramanian and J. Stephen Dumler

    Citation: Clinical Epigenetics 2015 7:77

    Content type: Research

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  47. Abnormal sex chromosome numbers in humans are observed in Turner (45,X) and Klinefelter (47,XXY) syndromes. Both syndromes are associated with several clinical phenotypes, whose molecular mechanisms are obscur...

    Authors: Amit Sharma, Muhammad Ahmer Jamil, Nicole Nuesgen, Felix Schreiner, Lutz Priebe, Per Hoffmann, Stefan Herns, Markus M. Nöthen, Holger Fröhlich, Johannes Oldenburg, Joachim Woelfle and Osman El-Maarri

    Citation: Clinical Epigenetics 2015 7:76

    Content type: Research

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  48. Ductal carcinoma in situ (DCIS) is a heterogeneous, pre-invasive lesion associated with an increased risk for future invasive ductal carcinoma. However, accurate risk stratification for development of invasive...

    Authors: Kevin C. Johnson, Devin C. Koestler, Thomas Fleischer, Panpan Chen, Erik G. Jenson, Jonathan D. Marotti, Tracy Onega, Vessela N. Kristensen and Brock C. Christensen

    Citation: Clinical Epigenetics 2015 7:75

    Content type: Research

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  49. Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the accumulation of pro-inflammatory signals, which constitutes a hallmark of cancer. To...

    Authors: Inês Cebola, Joaquin Custodio, Mar Muñoz, Anna Díez-Villanueva, Laia Paré, Patricia Prieto, Susanna Aussó, Llorenç Coll-Mulet, Lisardo Boscá, Victor Moreno and Miguel A. Peinado

    Citation: Clinical Epigenetics 2015 7:74

    Content type: Research

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