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  1. DNA methylation is an essential epigenetic mark, controlled by DNA methyltransferase (DNMT) proteins, which regulates chromatin structure and gene expression throughout the genome. In this study, we describe a...

    Authors: Kristin D. Kernohan, Laila Cigana Schenkel, Lijia Huang, Amanda Smith, Guillaume Pare, Peter Ainsworth, Kym M. Boycott, Jodi Warman-Chardon and Bekim Sadikovic

    Citation: Clinical Epigenetics 2016 8:91

    Content type: Short report

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  2. Antisense non-coding RNA in the INK4 locus (ANRIL) fixed genetic variants have consistently been linked with coronary heart disease (CHD) risk. We investigated relationships between perinatal ANRIL promoter DN...

    Authors: Robert Murray, Jennifer Bryant, Phil Titcombe, Sheila J. Barton, Hazel Inskip, Nicholas C. Harvey, Cyrus Cooper, Karen Lillycrop, Mark Hanson and Keith M. Godfrey

    Citation: Clinical Epigenetics 2016 8:90

    Content type: Short report

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  3. Associations between BMI and DNA methylation of hypoxia-inducible factor 3-alpha (HIF3A) in both blood cells and subcutaneous adipose tissue (SAT) have been reported. In this study, we investigated associations b...

    Authors: Ailsa Maria Main, Linn Gillberg, Anna Louisa Jacobsen, Emma Nilsson, Anette Prior Gjesing, Torben Hansen, Oluf Pedersen, Rasmus Ribel-Madsen and Allan Vaag

    Citation: Clinical Epigenetics 2016 8:89

    Content type: Research

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  4. Alterations in histone modifications are now well known to result in epigenetic heterogeneity in tumor tissues; however, their prognostic value and association with resection margins still remain poorly unders...

    Authors: Shafqat Ali Khan, Ramchandra Amnekar, Bharat Khade, Savio George Barreto, Mukta Ramadwar, Shailesh V. Shrikhande and Sanjay Gupta

    Citation: Clinical Epigenetics 2016 8:88

    Content type: Research

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  5. Immunoactivation is less evident in secondary progressive MS (SPMS) compared to relapsing-remitting disease. MicroRNA (miRNA) expression is integral to the regulation of gene expression; determining their impa...

    Authors: Katherine A. Sanders, Miles C. Benton, Rod A. Lea, Vicki E. Maltby, Susan Agland, Nathan Griffin, Rodney J. Scott, Lotti Tajouri and Jeannette Lechner-Scott

    Citation: Clinical Epigenetics 2016 8:87

    Content type: Research

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  6. DNA methylation of the Th1 and Th2 cytokine genes is altered during cow’s milk allergy (CMA). Forkhead box transcription factor 3 (FoxP3) is essential for the development and function of regulatory T cells (Tregs...

    Authors: Lorella Paparo, Rita Nocerino, Linda Cosenza, Rosita Aitoro, Valeria D’Argenio, Valentina Del Monaco, Carmen Di Scala, Antonio Amoroso, Margherita Di Costanzo, Francesco Salvatore and Roberto Berni Canani

    Citation: Clinical Epigenetics 2016 8:86

    Content type: Short report

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  7. Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular inflammation. Two prominent ANCA autoantigens are myeloperoxid...

    Authors: Jiajin Yang, Heng Ge, Caroline J. Poulton, Susan L. Hogan, Yichun Hu, Britta E. Jones, Candace D. Henderson, Elizabeth A. McInnis, William F. Pendergraft III, J. Charles Jennette, Ronald J. Falk and Dominic J. Ciavatta

    Citation: Clinical Epigenetics 2016 8:85

    Content type: Research

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  8. Tobacco smoke is worldwide one of the main preventable lifestyle inhalative pollutants causing severe adverse health effects. Epidemiological studies revealed association of tobacco smoking with epigenetic cha...

    Authors: Mario Bauer, Beate Fink, Loreen Thürmann, Markus Eszlinger, Gunda Herberth and Irina Lehmann

    Citation: Clinical Epigenetics 2016 8:83

    Content type: Research

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  9. Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. It is known that GDM is associated with an altered placental function and changes in placental gene regulation. More recent st...

    Authors: C. Reichetzeder, S. E. Dwi Putra, T. Pfab, T. Slowinski, C. Neuber, B. Kleuser and B. Hocher

    Citation: Clinical Epigenetics 2016 8:82

    Content type: Research

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  10. In utero and early-life experienced environmental exposures are suggested to play an important role in many multifactorial diseases potentially mediated through lasting effects on the epigenome. As the epigeno...

    Authors: Nicklas H. Staunstrup, Anna Starnawska, Mette Nyegaard, Lene Christiansen, Anders L. Nielsen, Anders Børglum and Ole Mors

    Citation: Clinical Epigenetics 2016 8:81

    Content type: Research

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  11. Epigenetic events mediated by methylation and histone modifications have been associated with the development of metastasis in patients with uveal melanoma. The role of epigenetic events mediated by microRNA (...

    Authors: Pierre L. Triozzi, Susan Achberger, Wayne Aldrich, John W. Crabb, Yogen Saunthararajah and Arun D. Singh

    Citation: Clinical Epigenetics 2016 8:80

    Content type: Research

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  12. Refractory and/or relapsed diffuse large B cell lymphoma (RR-DLBCL) patients are incurable with conventional chemotherapy due to the aggressiveness and the chemorefractory state of these tumors. DNA hypermethy...

    Authors: Benet Pera, Tiffany Tang, Rossella Marullo, Shao-Ning Yang, Haelee Ahn, Jayeshkumar Patel, Rebecca Elstrom, Jia Ruan, Richard Furman, John Leonard, Leandro Cerchietti and Peter Martin

    Citation: Clinical Epigenetics 2016 8:79

    Content type: Research

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  13. Vascular malformations are developmental congenital abnormalities of the vascular system which may involve any segment of the vascular tree such as capillaries, veins, arteries, or lymphatics. Arteriovenous ma...

    Authors: Jaya Mary Thomas, Sumi Surendran, Mathew Abraham, Arumugam Rajavelu and Chandrasekharan C. Kartha

    Citation: Clinical Epigenetics 2016 8:78

    Content type: Review

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    The Correction to this article has been published in Clinical Epigenetics 2018 10:124

  14. Obesity is a metabolic disease caused by environmental and genetic factors. However, the epigenetic mechanisms of obesity are incompletely understood. The aim of our study was to investigate the role of skelet...

    Authors: Samantha E. Day, Richard L. Coletta, Joon Young Kim, Latoya E. Campbell, Tonya R. Benjamin, Lori R. Roust, Elena A. De Filippis, Valentin Dinu, Gabriel Q. Shaibi, Lawrence J. Mandarino and Dawn K. Coletta

    Citation: Clinical Epigenetics 2016 8:77

    Content type: Research

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  15. DNA methylation profiling of heterogeneous head and neck squamous cell carcinoma (HNSCC) cohorts has been reported to predict patient outcome. We investigated if a prognostic DNA methylation profile could be f...

    Authors: Annette M. Lim, Nicholas C. Wong, Ruth Pidsley, Elena Zotenko, June Corry, Alexander Dobrovic, Susan J. Clark, Danny Rischin and Benjamin Solomon

    Citation: Clinical Epigenetics 2016 8:74

    Content type: Research

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  16. Human methylome mapping in health and disease states has largely relied on Illumina Human Methylation 450k array (450k array) technology. Accompanying this has been the necessary evolution of analysis pipeline...

    Authors: Emma Cazaly, Russell Thomson, James R. Marthick, Adele F. Holloway, Jac Charlesworth and Joanne L. Dickinson

    Citation: Clinical Epigenetics 2016 8:75

    Content type: Methodology

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  17. Aberrant patterns of DNA methylation are abundant in cancer, and epigenetic pathways are increasingly being targeted in cancer drug treatment. Genetic components of the folate-mediated one-carbon metabolism pa...

    Authors: Julia Krushkal, Yingdong Zhao, Curtis Hose, Anne Monks, James H. Doroshow and Richard Simon

    Citation: Clinical Epigenetics 2016 8:73

    Content type: Research

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  18. Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of developing obesity and type 2 diabetes. This susceptibility might involve brown adipose tissue (BAT), which is suspected to prote...

    Authors: Sandra Côté, Valérie Gagné-Ouellet, Simon-Pierre Guay, Catherine Allard, Andrée-Anne Houde, Patrice Perron, Jean-Patrice Baillargeon, Daniel Gaudet, Renée Guérin, Diane Brisson, Marie-France Hivert and Luigi Bouchard

    Citation: Clinical Epigenetics 2016 8:72

    Content type: Research

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  19. The azanucleosides azacitidine and decitabine are currently used for the treatment of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) in patients not only eligible for intensive chemotherapy b...

    Authors: Jeannine Diesch, Anabel Zwick, Anne-Kathrin Garz, Anna Palau, Marcus Buschbeck and Katharina S. Götze

    Citation: Clinical Epigenetics 2016 8:71

    Content type: Review

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  20. Intrauterine growth restriction (IUGR), which refers to reduced fetal growth in the context of placental insufficiency, is etiologically heterogeneous. IUGR is associated not only with perinatal morbidity and ...

    Authors: Maian Roifman, Sanaa Choufani, Andrei L. Turinsky, Sascha Drewlo, Sarah Keating, Michael Brudno, John Kingdom and Rosanna Weksberg

    Citation: Clinical Epigenetics 2016 8:70

    Content type: Research

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  21. The overgrowth-associated Beckwith-Wiedemann syndrome (BWS) and the undergrowth-associated Silver-Russell syndrome (SRS) are characterized by heterogeneous molecular defects affecting a large imprinted gene cl...

    Authors: Susanne Eriksen Boonen, Andrea Freschi, Rikke Christensen, Federica Maria Valente, Dorte Launholt Lildballe, Lucia Perone, Orazio Palumbo, Massimo Carella, Niels Uldbjerg, Angela Sparago, Andrea Riccio and Flavia Cerrato

    Citation: Clinical Epigenetics 2016 8:69

    Content type: Short report

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  22. Aberrant DNA methylation has been identified as a key molecular event regulating the pathogenesis of myelodysplastic syndromes (MDS); myeloid neoplasms with an inherent risk of transformation to acute myeloid ...

    Authors: Seongseok Yun, Nicole D. Vincelette, Ivo Abraham, Keith D. Robertson, Martin E. Fernandez-Zapico and Mrinal M. Patnaik

    Citation: Clinical Epigenetics 2016 8:68

    Content type: Review

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  23. Preeclampsia, traditionally characterized by high blood pressure and proteinuria, is a common pregnancy complication, which affects 2–8 % of all pregnancies. Although children born to women with preeclampsia h...

    Authors: Masako Suzuki, Ryo Maekawa, Nicole E. Patterson, David M. Reynolds, Brent R. Calder, Sandra E. Reznik, Hye J. Heo, Francine Hughes Einstein and John M. Greally

    Citation: Clinical Epigenetics 2016 8:67

    Content type: Research

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  24. Opportunistic screening in hospitals is widely used to effectively reduce the incidence rate of cervical cancer in China and other developing countries. This study aimed to identify clinical risk factor algori...

    Authors: Yu-Ligh Liou, Tao-Lan Zhang, Tian Yan, Ching-Tung Yeh, Ya-Nan Kang, Lanqin Cao, Nayiyuan Wu, Chi-Feng Chang, Huei-Jen Wang, Carolyn Yen, Tang-Yuan Chu, Yi Zhang, Yu Zhang and Honghao Zhou

    Citation: Clinical Epigenetics 2016 8:66

    Content type: Case study

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  25. Crohn’s disease (CD) is a chronic inflammatory disorder belonging to the inflammatory bowel diseases (IBD). CD affects distinct parts of the gastrointestinal tract, leading to symptoms including diarrhea, feve...

    Authors: Andrew Y. F. Li Yim, Nicolette W. Duijvis, Jing Zhao, Wouter J. de Jonge, Geert R. A. M. D’Haens, Marcel M. A. M. Mannens, Adri N. P. M. Mul, Anje A. te Velde and Peter Henneman

    Citation: Clinical Epigenetics 2016 8:65

    Content type: Research

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  26. Previous studies have developed models predicting methylation age from DNA methylation in blood and other tissues (epigenetic clock) and suggested the difference between DNA methylation and chronological ages ...

    Authors: Laura Perna, Yan Zhang, Ute Mons, Bernd Holleczek, Kai-Uwe Saum and Hermann Brenner

    Citation: Clinical Epigenetics 2016 8:64

    Content type: Research

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  27. When assembled in multiprotein polycomb repressive complexes (PRCs), highly evolutionary conserved polycomb group (PcG) proteins epigenetically control gene activity. Although the composition of PRCs may vary ...

    Authors: Koraljka Gall Trošelj, Renata Novak Kujundzic and Djurdjica Ugarkovic

    Citation: Clinical Epigenetics 2016 8:55

    Content type: Review

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  28. Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, ...

    Authors: Yong Wang, Fei Li, Guowei Zhang, Lihua Kang and Huaijin Guan

    Citation: Clinical Epigenetics 2016 8:62

    Content type: Research

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  29. Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferatio...

    Authors: Vincenzo Carafa, Dante Rotili, Mariantonietta Forgione, Francesca Cuomo, Enrica Serretiello, Gebremedhin Solomon Hailu, Elina Jarho, Maija Lahtela-Kakkonen, Antonello Mai and Lucia Altucci

    Citation: Clinical Epigenetics 2016 8:61

    Content type: Review

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  30. The quantification of global DNA methylation has been established in epigenetic screening. As more practicable alternatives to the HPLC-based gold standard, the methylation analysis of CpG islands in repeatabl...

    Authors: Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring and Jörn Lötsch

    Citation: Clinical Epigenetics 2016 8:60

    Content type: Methodology

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  31. Prenatal maternal stress (PNMS) is an important programming factor of postnatal immunity. We tested here the hypothesis that DNA methylation of genes in the NF-κB signaling pathway in T cells mediates the effe...

    Authors: Lei Cao-Lei, Franz Veru, Guillaume Elgbeili, Moshe Szyf, David P. Laplante and Suzanne King

    Citation: Clinical Epigenetics 2016 8:54

    Content type: Research

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  32. The tumor-specific microregional effects of the anticancer agent RRx-001, a novel epigenetic-based radio/chemosensitizer with nitrogen oxide-donating properties in phase II clinical trials, were investigated w...

    Authors: Bryan Oronsky, Jan Scicinski, Pedro Cabrales and Andrew Minchinton

    Citation: Clinical Epigenetics 2016 8:53

    Content type: Research

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  33. Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found signifi...

    Authors: Anna Starnawska, Ditte Demontis, Andrew McQuillin, Niamh L. O’Brien, Nicklas H. Staunstrup, Ole Mors, Anders L. Nielsen, Anders D. Børglum and Mette Nyegaard

    Citation: Clinical Epigenetics 2016 8:52

    Content type: Short report

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  34. Epigenetic reprogramming in mammalian gametes resets methylation marks that regulate monoallelic expression of imprinted genes. In males, this involves erasure of the maternal methylation marks and establishme...

    Authors: Adelheid Soubry, Lisa Guo, Zhiqing Huang, Cathrine Hoyo, Stephanie Romanus, Thomas Price and Susan K. Murphy

    Citation: Clinical Epigenetics 2016 8:51

    Content type: Research

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  35. Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative neoplasm of childhood whose clinical heterogeneity is only poorly represented by gene sequence alterations. It was previously shown that aberrant...

    Authors: Silvia Fluhr, Melanie Boerries, Hauke Busch, Aikaterini Symeonidi, Tania Witte, Daniel B Lipka, Oliver Mücke, Peter Nöllke, Christopher Felix Krombholz, Charlotte M Niemeyer, Christoph Plass and Christian Flotho

    Citation: Clinical Epigenetics 2016 8:50

    Content type: Short report

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  36. The DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) causes resistance of cancer cells to alkylating agents and, therefore, is a well-established predictive marker for high-grade gliomas that are ...

    Authors: Olivier J. Switzeny, Markus Christmann, Mirjam Renovanz, Alf Giese, Clemens Sommer and Bernd Kaina

    Citation: Clinical Epigenetics 2016 8:49

    Content type: Research

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  37. Chronic hepatitis B infection is characterized by hepatic immune and inflammatory response with considerable variation in the rates of progression to cirrhosis. Genetic variants and environmental cues influenc...

    Authors: Müjdat Zeybel, Sezgin Vatansever, Timothy Hardy, Ayşegül Akder Sarı, Fulya Cakalağaoğlu, Arzu Avcı, Gemma Louise Zeybel, Serçin Karahüseyinoğlu, Matthew Bashton, John C. Mathers, Belkıs Ünsal and Jelena Mann

    Citation: Clinical Epigenetics 2016 8:48

    Content type: Research

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  38. Genomic imprinting evolved in a common ancestor to marsupials and eutherian mammals and ensured the transcription of developmentally important genes from defined parental alleles. The regulation of imprinted g...

    Authors: Florian Bohne, David Langer, Ursula Martiné, Claudia S. Eider, Regina Cencic, Matthias Begemann, Miriam Elbracht, Luzie Bülow, Thomas Eggermann, Ulrich Zechner, Jerry Pelletier, Bernhard Ulrich Zabel, Thorsten Enklaar and Dirk Prawitt

    Citation: Clinical Epigenetics 2016 8:47

    Content type: Research

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  39. 5-Azacytidine (5-AZA), a DNA methyl transferase inhibitor, is a clinically used epigenetic drug for cancer therapy. Recently, we have shown that 5-AZA upregulates ten-eleven translocation (TET) protein express...

    Authors: Sahar Olsadat Sajadian, Chaturvedula Tripura, Fazel Sahraneshin Samani, Marc Ruoss, Steven Dooley, Hossein Baharvand and Andreas K. Nussler

    Citation: Clinical Epigenetics 2016 8:46

    Content type: Research

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  40. The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic methods to improve accuracy and reproducibility of the interpretation of r...

    Authors: Michelle L. Wright, Mikhail G. Dozmorov, Aaron R. Wolen, Colleen Jackson-Cook, Angela R. Starkweather, Debra E. Lyon and Timothy P. York

    Citation: Clinical Epigenetics 2016 8:45

    Content type: Review

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  41. Already since the 1990s, promoter CpG island methylation markers have been considered promising diagnostic, prognostic, and predictive cancer biomarkers. However, so far, only a limited number of DNA methylati...

    Authors: Muriel X. G. Draht, Kim M. Smits, Valérie Jooste, Benjamin Tournier, Martijn Vervoort, Chantal Ramaekers, Caroline Chapusot, Matty P. Weijenberg, Manon van Engeland and Veerle Melotte

    Citation: Clinical Epigenetics 2016 8:44

    Content type: Research

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  42. Related to genetic alteration, frequent promoter hypermethylation is also a contributing factor in the development of human cancers. Recently, we discovered numerous novel genes that were aberrantly methylated...

    Authors: Yu-Lueng Shih, Chih-Chi Kuo, Ming-De Yan, Ya-Wen Lin, Chung-Bao Hsieh and Tsai-Yuan Hsieh

    Citation: Clinical Epigenetics 2016 8:41

    Content type: Research

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