DNA methylation of imprint control regions associated with Alzheimer’s disease in non-Hispanic Blacks and non-Hispanic Whites

Table 2 AD associated differentially methylated regions overlapping ICR_20 (CASZ1), ICR_1027 (RBFOX3), ICR_987 (NLRP1) and ICR_481 (MEST/MESTIT1)

Gene ID	ICR_ID	DMR coordinates	Race/ethnicity	Mean methylation ratio in controls	Mean methylation ratio in ADs	Credible methylation difference (CDIF)	p−value	Methylation
CASZ1	ICR_20	chr1: 10682586–10683160	NHB	0.395	0.912	0.227	1.07E−33	Strong-Hyper
CASZ1	ICR_20	chr1: 10682972–10683160	ALL	0.52	0.939	0.218	4.69E−23	Strong-Hyper
RBFOX3	ICR_1027	chr17: 79517720–79517977	NHB	0.319	0.869	0.208	1.68E−25	Strong-Hyper
		chr17:79518326–79518634	NHB	0.272	0.716	0.166	1.85E−16	Strong-Hyper
		chr17: 79517916–79517973	ALL	0.449	0.83	0.167	1.27E−09	Strong-Hyper
NLRP1	ICR_987	chr17:5771278–5771364	NHB	0.144	0.679	0.138	4.64E−21	Strong-Hyper
		chr17:5771284–5771340	NHW	0.162	0.828	0.218	1.26E−09	Strong-Hyper
		chr17:5771252–5771364	ALL	0.194	0.744	0.257	2.41E−50	Strong-Hyper
MEST\|MESTIT1	ICR_481	chr7: 130494195–130494648	NHB	0.738	0.345	-0.159	1.08E−09	Strong-Hypo
		chr7: 130492063–130492131	NHW	0.69	0.178	-0.155	2.02E−14	Strong-Hypo
		chr7: 130492246–130492270	ALL	0.541	0.162	-0.137	2.16E−09	Strong-Hypo
		chr7: 130494195–130494648	ALL	0.73	0.443	-0.118	7.50E−09	Strong-Hypo

ISSN: 1868-7083