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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma

Fig. 5

A EZH2 regulates the function of HNSCC. A Molecular structure of EZH2 (UniProt, 751 amino acids, isoform a). SANT: SANT SWI3, ADA2, N-CoR and TFIIIB” DNA-binding domain, CXC: Tesmin/TSOl-like CXC domain, SET: Su (var)3–9, Enhancer-of-zeste, Trithorax. B EZH2 serves as an upstream mediator of non-coding RNAs expression in HNSCC and is associated with the STAT3 pathway. Due to its transcriptional role, this pathway can target miRNAs to affect cancer cell proliferation, drug resistance, EMT process, and invasion, thereby determining cancer cell response to treatment

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Clinical Epigenetics

ISSN: 1868-7083

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