Fig. 3
The inhibitory effect of selenium on histone demethylases in cervical cancer. A Selenium treatment led to a reduction in the expression of JMJD3 and UTX in HeLa and SiHa cells. B An increase in H3K27me3, a marker of histone methylation, in the nuclei of HeLa and SiHa cells following selenium treatment. (Scale bar = 20 μm). C Selenium induced a decrease in the expression of JMJD3 and UTX in subcutaneous xenograft tumors of cervical cancer (n = 3). *p < 0.05; **p < 0.01; ****p < 0.0001, ns p > 0.05 compared with Ctrl