Fig. 1
The use of selenium as a treatment demonstrated significant inhibition of various biological behaviors in cervical cancer cells. The impact on cell proliferation and clonogenic ability was evaluated using the CCK-8 assay (A) and colony formation assay (B) in HeLa and SiHa cells. C Apoptosis induction was observed in both cell lines through flow cytometric analysis. D The effects of SeO2 treatment on cell migration and invasion were assessed using the wound healing assay (scale bar = 100 μm) and E Transwell chamber experiments (scale bar = 100 μm) in HeLa and SiHa cells. SeO2 treatment led to a significant decrease in cell migration and invasion abilities in both cell lines (n = 3). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 compared with PBS-treated Ctrl