Table 1 Demographics of cohort comparing ddPCR and EPIC array cg05575921 values
From: A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
Total | Never smoked | Ex-smoker | Current smoker | |
|---|---|---|---|---|
Number | 1227 | 450 | 630 | 147 |
Sex, n of males (%) | 871 (71.0) | 300 (66.7) | 473 (75.1) | 98 (66.9) |
Age (years) | 70.1 ± 8.2 | 70.8 ± 7.6 | 70.6 ± 8.2 | 65.6 ± 8.9 |
Smoking pack years | 7 (0–30) | 0 | 20 (8–38) | 34 (21–48) |
History of cardiovascular disease* | 708 (57.7) | 214 (47.6) | 367 (58.3) | 127 (86.4) |
cg05575921, Illumina array % DNA methylation | 78.3 ± 12.2 | 84.7 ± 7.3 | 77.6 ± 10.8 | 61.4 ± 12.8 |
cg05575921, RE ddPCR % DNA methylation | 75.8 ± 16.2* | 84.7 ± 8.3 | 75.4 ± 14.2* | 50.5 ± 15.3* |