Fig. 1
From: A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
Relative sensitivity and specificity of cg05575921 assays detection of smoking status. DNA methylation values for cg05575921 derived from Illumina EPIC assays (GS normalised) and RE ddPCR were significantly predictive of smoking status (all AUCs P < 0.0001), however, the RE ddPCR assay was significantly more sensitive and specific in differentiating between A never and current smokers and C Ex and current smokers. B There was no significant difference in the predictive performance of either assay to distinguish between never and ex-smokers. Confusion matrices, tabulating the positive and negative predictive performances, are shown in Additional file 1: Sheet S3, Table 2.