Fig. 8

Graphic illustration of proposed mechanism of miR-20b-5p/TET2 axis in cardiac differentiation. The epigenetic mechanism of miR-20b-5p/TET2 axis in cardiac differentiation is illustrated whereby miR-20b-5p acts as an inhibitory regulator in hESCs-derived cardiac differentiation by targeting TET2, leading to suppression of 5-hydroxymethylcytosine and cardiac-specific genes expression. These findings indicate that miR-20b-5p could be a potential biomarker for ASD