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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation

Fig. 2

MiRNAs expression profiling during hESCs-derived cardiac differentiation. A Principal component (PC) analysis of miRNAs during 12-day cardiac differentiation of hESCs (n = 3). B Volcano plot of differentially expressed miRNAs in 12-day cardiac-differentiated hESCs. The red and green dots represented significantly upregulated and downregulated miRNAs in Day 12 group, respectively (n = 3). C Heatmap of remarkably downregulated miRNAs relative to cardiovascular disease during 12-day cardiac differentiation of hESCs (|log2FC|≥ 1.2, P < 0.05, n = 3). D Heatmap of markedly upregulated miRNAs relative to cardiovascular disease during 12-day cardiac differentiation of hESCs (|log2FC|≥ 1.2, P < 0.05, n = 3). D0, D3, D6, D9 and D12 indicated the time points at Day 0, Day 3, Day 6, Day 9 and Day 12, respectively

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Clinical Epigenetics

ISSN: 1868-7083

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