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Fig. 1 | Clinical Epigenetics

Fig. 1

From: MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2

Fig. 1

Visualisation of the expression and correlative relationship of the DEG pair: MAL- AC103563.8. A Unsupervised hierarchical clustering demarcating the CaCx patients from the normal individuals based on MAL and AC103563.8 gene expression profiles. The heatmap represents normalised counts, which were log2 transformed after adding constant 1 to all values of genes. The rows represent the gene names, and the columns represent the samples (blue bar represents the CaCx patient samples and pink bar represents the samples from normal individuals). Pearson’s correlation coefficient of MAL and AC103563.8 among (B) CaCx cases and (C) normal healthy individuals, respectively. Real-time qPCR based relative expression of D MAL and E AC103563.8 (MAL-AS1) in an additional cohort of HPV16-positive CaCx patients compared to healthy individuals. Relative gene expression reflects expression of the gene minus expression of the house-keeping gene (GAPDH), and is inversely proportional to the fold change. Thus, higher relative gene expression designates lower fold change. The data are represented as mean ± SD

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Clinical Epigenetics

ISSN: 1868-7083

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